健康体检成人FibroScan检测肝脏硬度值与年龄、性别的相关性  

Correlation of liver stiffness measured by Fibro Scan with sex and age in healthy adults undergoing physical examination

作　　者：赵崇山[1] 何文艳[1] 王宁方[2] 耿华[1] 安红杰[1] 赵宝生[1] 高美丽[1] 徐金凤[1] 

机构地区：[1]中国石油天然气集团公司中心医院感染科,河北廊坊065000 [2]中国石油天然气集团公司中心医院血液科,河北廊坊065000

出　　处：《临床肝胆病杂志》2016年第4期724-727,共4页Journal of Clinical Hepatology

基　　金：廊坊市科技计划项目(2014-013003)

摘　　要：目的界定正常人群肝脏硬度值参考范围及探讨年龄、性别对肝脏硬度值的影响。方法收集2012年10月1日^(-2)014年10月31日于中国石油天然气集团公司中心医院进行体检的健康人群1794例,经Fibro Scan进行肝脏硬度值(LSM)检测。因LSM的分布不服从正态分布,采用Wilcoxon秩和检验比较不同性别组间LSM;采用Kruskal-Wallis检验比较不同年龄段间LSM,采用Spearman秩相关分析LSM与年龄的相关性;采用单侧百分位法制订性别、年龄段的正常参考值范围。结果其中1590例LSM测定成功有效,有效率为88.63%,107例因肝功能异常被剔除,经分析发现男性受试者LSM高于女性受试者,男女间比较LSM差异有统计学意义(Z=-4.980,P<0.001);不同年龄段间LSM差异亦有统计学意义(χ~2=16.983,P=0.001),并证实年龄与LSM呈正相关(r=0.087,P=0.001),参考范围(P90)估计:成人≤7.1 k Pa,女性≤7.0 k Pa,男性≤7.2 k Pa;按年龄划分20~29岁≤6.8 k Pa,30~44岁≤6.7 k Pa,45~59岁≤7.8 k Pa,60~74岁≤8.8 k Pa。结论 LSM受年龄、性别影响,在体检人群中应用时需根据年龄、性别参考相应的医学参考值范围。Objective To determine the reference range of liver stiffness in healthy population,and to investigate the influence of age and sex on liver stiffness. Methods A total of 1794 healthy subjects who underwent physical examination in China National Petroleum Corporation Central Hospital from October 1,2012 to October 31,2014 were enrolled,and Fibro Scan was used to perform liver stiffness measurement（ LSM）. Since LSM value was not normally distributed,the Wilcoxon rank sum test was used to compare LSM value between male and female patients,the Kruskal- Wallis test was used to compare LSM value between different age groups,and the Spearman＇s rank correlation analysis was used to analyze the correlation between LSM value and age. The one- sided percentile method was used to determine the range of normal reference values in male and female subjects or in different age groups. Results LSM was successfully performed in 1590 patients,and the rate of successful measurement was 88. 63%. A total of 107 patients were excluded due to abnormal liver enzymes. The analysis showed that LSM value showed a significant difference between male and female subjects（ Z =- 4. 980,P〈0. 001）,as well as between different age groups（ χ-2= 16. 983,P = 0. 001）. Age was positively correlated with LSM value（ r = 0. 087,P = 0. 001）. The reference range was estimated to be ≤7. 1 k Pa in adults,≤7. 0 k Pa in females,and ≤7. 2 k Pa in males. From the perspective of age,the reference range was estimated to be ≤6. 8 k Pa in persons aged 20- 29 years,≤6. 7 k Pa in persons aged 30- 44 years,≤7. 8 k Pa in persons aged 45- 59 years,and ≤8. 8 k Pa in persons aged 60- 74 years. Conclusion Liver stiffness value is influenced by sex and age. Sex and age should be taken into account while performing liver stiffness measurement in healthy subjects.

关 键 词：弹性成像技术 肝脏硬度值 性别因素 年龄分布 参考值 

分 类 号：R575[医药卫生—消化系统]