NOB1在肝癌组织中的表达及意义  

Expression of NOB1 in liver cancer tissues and its significance

作　　者：赵丽娟[1] 李志锋[2] 石荣亚[1] 杨宁[2] 刘进忠[2] 

机构地区：[1]河北省保定市第一医院消化科,河北保定071000 [2]河北省保定市第一医院普外科,河北保定071000

出　　处：《临床肝胆病杂志》2016年第4期739-741,共3页Journal of Clinical Hepatology

摘　　要：目的检测NOB1在肝癌组织中的表达情况,了解NOB1与肝癌临床病理特征的关系。方法收集2011年2月^(-2)015年5月于河北省保定市第一医院行肝癌手术的标本48例,收集肝硬化组织22例、正常肝组织22例作为对照,应用免疫组化SP法检测NOB1在不同肝组织中的表达情况,并分析肝癌组织中NOB1的表达与临床病理因素的关系。计数资料组间比较采用χ~2检验。结果 NOB1在肝癌组织中表达的阳性率(72.9%)明显高于肝硬化组织(36.4%)和正常肝组织(31.8%)(P值分别为0.004、0.001);在肝硬化组织和正常肝组织中的表达差异无统计学意义(P>0.05)。NOB1表达阳性率在肿瘤直径>5 cm组明显高于肿瘤直径≤5 cm组(χ~2=4.355,P=0.037),Edmondson分级Ⅲ、Ⅳ级明显高于Ⅰ、Ⅱ级(χ~2=5.127,P=0.024)。与患者年龄、性别、有无微血管浸润、有无淋巴结转移及临床TNM分期无关(P值均>0.05)。结论 NOB1在肝癌组织中高表达,与肝癌的肿瘤大小、Edmondson分级密切相关,可作为肝癌重要的肿瘤标志物。Objective To measure the expression of NOB1 in liver cancer tissues,and to investigate the relationship between NOB1 and clinicopathological features of liver cancer. Methods A total of 48 liver cancer samples were collected from the patients who underwent liver cancer surgery in our hospital from February 2011 to May 2015,and 22 samples of cirrhotic liver tissues and 22 samples of normal liver tissues were collected as controls. The immunohistochemical SP method was used to measure the expression of NOB1 in different tissues,and the relationship between the expression of NOB1 and clinicopathological features was analyzed. The chi- square test was applied for comparison of categorical data between groups. Results The expression of NOB1 in liver cancer tissues was significantly higher than that in cirrhotic liver tissues and normal liver tissues（ 72. 9% vs 36. 4% /31. 8%; P = 0. 004 and 0. 001）,while the expression of NOB1 showed no significant difference between cirrhotic liver tissues and normal liver tissues（ P〈0. 05）. The patients with a tumor diameter of 5 cm had a significantly higher positive rate of NOB1 than those with a tumor diameter of ≤5 cm（ χ-2= 4. 355,P = 0. 037）,and the patients with Edmondson grade Ⅲ / Ⅳ tumor had a significantly higher positive rate of NOB1 than those with Edmondson grade Ⅰ / Ⅱ tumor（ χ-2= 5. 127,P = 0. 024）. The expression of NOB1 in liver cancer tissues was not correlated with age,sex,presence or absence of microvascular invasion,presence or absence of lymph node metastasis,and clinical TNM stage（ all P〈0. 05）. Conclusion NOB1 is highly expressed in liver cancer tissues. The expression of NOB1 is closely related to tumor size and Edmondson grade,and can be used as an important tumor marker for liver cancer.

关 键 词：肝肿瘤 NOB1蛋白 

分 类 号：R735.7[医药卫生—肿瘤]