瘦人非酒精性脂肪性肝病的临床特征  

Characteristics of lean patients with non-alcoholic fatty liver disease

作　　者：郭翃江[1] 严之红[1] 纪红[1] 

机构地区：[1]航天中心医院,北京100049

出　　处：《中国肝脏病杂志（电子版）》2016年第1期72-75,共4页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的研究瘦人非酒精性脂肪性肝病(NAFLD)的临床特征。方法从参加常规体检的1196例成人中,纳入219例诊断为NAFLD的患者,对瘦人[体质指数(BMI)<24 kg/m^2]与超重或肥胖(BMI≥24 kg/m^2)NAFLD患者的人口统计学、人体测量学、实验室检测指标和代谢并发症等特征进行比较。结果 219例NAFLD患者中,38例(17.4%)瘦人与181例(82.6%)超重或肥胖患者相比,男性比例更高(76.3%vs.58.6%,P=0.037),年龄较轻[(36.8±11.3)岁vs.(43.4±13.6)岁,P=0.006],舒张压[(83.7±7.5)mmHg vs.(83.1±8.2)mmHg]、收缩压[(129.6±7.8)mmHg vs.(131.4±9.3)mmHg]、空腹血糖[(5.46±0.83)μmol/L vs.(5.39±0.79)μ.mol/L]、总胆固醇[(6.48±1.37)mmol/L vs.(6.17±1.56)mmo/L、甘油三酯[(3.24±1.09)mmol/L vs.(3.32±0.94)mmol/L]、尿酸[(392.8±61.7)μmol/L vs.(388.5±59.6)μmol/L]和丙氨酸氨基转移酶[(32.6±8.9)IU/L vs.(31.3±9.6)IU/L]水平差异均无显著统计学意义(P值分别为0.906、0.395、0.725、0.326、0.837、0.864、0.416),高血压(28.9%vs.32.0%)、高血糖(26.3%vs.25.4%)、血脂异常(78.9%vs.76.2%)和高尿酸血症(34.2%vs.35.4%)患病率差异无统计学意义(P值分别为0.764、0.526、0.872、0.231)。结论与超重或肥胖患者相比,瘦人NAFLD患者的男性比例更高,年龄较轻,高血压、高血糖、血脂异常和高尿酸血症等代谢并发症的患病率无统计学差异。Objective To discuss the characteristics of lean patients with non-alcoholic fatty liver disease （NAFLD）. Methods The data of 1196 adults who underwent routine health checkups were studied, of which 219 patients diagnosed with NAFLD were included in the final analysis. The demographic, somatometric, laboratory and metabolic comorbidities characteristics of lean patients [body mass index （BMI） 〈 24 kg/m2] with NAFLD were compared with those of overweight or obese patients （BMI 〉/24 kg/m2）. Results Of 219 patients with NAFLD, 38 （17.4%） were lean and 181 （82.6%） were overweight or obese. Lean patients were more male predominating （76.3% vs. 58.6%, P = 0.037） and younger [（36.8 ± 11.3） years old vs.（43.4 ± 13.6） years old, P = 0.006） compared with overweight or obese patients, whereas the levels of diastolic pressure [（83.7 ± 7.5） mmHg vs. （83.1 ± 8.2） mmHg], systolic pressure [（129.6 ±7.8） mmHg vs. （131.4 ± 9.3） mmHg], fasting blood glucose [（5.46 ± 0.83） μmol/L vs. （5.39 ± 0.79） μmol/L], total cholesterol [（6.48 ± 1.37） mmol/L vs. （6.17 ± 1.56） mmol/L], triglycerides [（3.24±1.09） mmol/L vs. （3.32±0.94） mmol/L], uric acid [（392.8±61.7） μmol/L vs. （388.5± 59.6）μ mol/L] and alanine aminotransferase [（32.6 ±8.9） IU/L vs. （31.3 ± 9.6） IU/L] had no statistical difference （P = 0.906, 0.395, 0.725, 0.326, 0.837, 0.864 and 0.416, respectively）. The prevalences of hypertension （28.9% vs. 32.0%）, hyperglycemia （26.3% vs. 25.4%）, dyslipidemia （78.9% vs. 76.2%） and hypenLricemia （34.2% vs. 35.4%） in lean patients had no statistical difference compared with overweight or obese patients （P = 0.764, 0.526, 0.872 and 0.231, respectively）. Conclusion Lean patients with NAFLD were more male predominating and younger compared with overweight or obese patients, whereas the prevalences of metabolic comorbidities such as hypertension, hyperglycemia, dyslipidemia and hypemricemia had no statistical dif

关 键 词：脂肪肝 非酒精性 瘦人 肥胖 代谢并发症 

分 类 号：R575.5[医药卫生—消化系统]