吲哚氰绿排泄试验在不同程度肝纤维化检测中的应用  

Application of ICG secretion test in investigation of different levels of liver fibrosis

作　　者：丁俊 杨美平[2] 张家耀 闫军 

机构地区：[1]湖北省恩施土家族苗族自治州中心医院,湖北恩施445500 [2]湖北民族学院附属民大医院,湖北恩施445000 [3]第三军医大学第一附属医院,重庆401300

出　　处：《中国肝脏病杂志（电子版）》2016年第1期85-89,共5页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的通过吲哚氰绿(ICG)排泄试验检测肝脏纤维化指标和INF-γ综合推断肝脏纤维化程度。方法选择2012年1月至2013年10月第三军医大学西南医院诊断为肝纤维化肝硬化的患者129例为试验组,正常体检健康者19例为对照组,检测肝纤维化指标和INF-γ,同时对试验组进行肝组织活检而确定肝纤维化程度,利用ICG排泄试验检测试验组的K值和R15。运用SPSS 17.0软件对数据进行统计分析。结果 K值和R15在五个纤维化程度(S_0、S_1、S_2、S_3、S_4)不同的病理类型中有显著差异;肝纤维化指标在S_0、S_1、S_2、S_3组中有显著差异,在S_4组和S_3组中无显著差异性。结论吲哚氰绿排泄试验可能成为推断肝纤维化程度的新指标和方法。Objective To investigate the level of liver fibrosis by detecting liver fibrosis indexes and INF-y through ICG secretion test comprehensively. Methods Total of 129 patients with liver fibrosis and cirrhosis in the First Affiliated Hospital of Third Military Medical University from January 2012 to October 2013 were selected as the experimental group, and 19 healthy people as the control group. Liver fibrosis markers and INF-y were detected. The pathological diagnosis of liver biopsy was performed to determine the level of liver fibrosis. The K value and R15 of the experimental group were detected by ICG secretion test. SPSS 17.0 software was used to analyze the data. Results The K value and R15 had significant differences in five different degrees of fibrosis （S0, S1, S2, S3 and S4） pathological type; liver fibrosis markers showed significant differences in SO, S1, S2, S3 groups, and there was no significant difference between S4 and S3 group. Conclusion ICG could be the new indicator and method to investigate the level of liver fibrosis.

关 键 词：ICG排泄试验 肝硬化 检测 

分 类 号：R575.2[医药卫生—消化系统]