和田昆仑雪菊降压活性部位初步筛选  

The Preliminary Screening of Antihypertension Activity Effective Parts for Hotan Coreopsis tinctoria Nutt.

作　　者：郭玉婷[1] 王丹[2] 程雪珊 陈阳[2] 段沐含 兰卫[2] 

机构地区：[1]新疆医科大学对口协作办公室,新疆乌鲁木齐830011 [2]新疆医科大学中医学院,新疆乌鲁木齐830011 [3]新疆医科大学科技处,新疆乌鲁木齐830011

出　　处：《云南中医学院学报》2016年第2期8-10,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：新疆维吾尔自治区科技成果转化项目(201254107)

摘　　要：目的昆仑雪菊降压活性有效部位的初步筛选。方法取30只健康家兔随机分为正常对照组、卡托普利组、雪菊石油醚萃取部位组、乙酸乙酯萃取部位组、正丁醇萃取部位组和水部位组,耳缘静脉注射给药,应用BL-420F生物机能实验系统记录仪观察各组家兔动脉血压的变化情况。结果与正常对照组相比,雪菊乙酸乙酯萃取部位组、正丁醇萃取部位组以及水部位组家兔动脉收缩压均显著下降(P<0.05);雪菊乙酸乙酯萃取部位组家兔动脉舒张压下降极其明显(P<0.01),水部位组家兔动脉舒张压有显著性差异(P<0.05)。结论昆仑雪菊乙酸乙酯、正丁醇和水萃取部位均可使家兔的血压明显下降。Objective The preliminary screening of antihypertension activity effective parts for Coreopsis tinctoria Nutt.Methods 30 healthy rabbits were randomly divided into normal control group,captopril group,Coreopsis tinctoria Nutt. Petroleum ether extraction parts group,the ethyl acetate extract group and n-butyl alcohol extraction and water parts group,ar vein injection,application BL-420 F biological and functional experimental system logger observe the changes of arterial blood pressure of rabbits in each group. Results Compared with normal control group,Coreopsis tinctoria Nutt. the ethyl acetate extract group and n-butyl alcohol extraction,water parts group,rabbits were significantly lower systolic blood pressure（P 0.05）,the ethyl acetate extract group rabbit arterial diastolic blood pressure decreased very significantly（P〈0.01）,and water parts group rabbit artery diastolic blood pressure has significant differences（P〈0.05）. Conclusion Coreopsis tinctoria Nutt. the ethyl acetate extract group and n-butyl alcohol extraction and water parts group can make blood pressure was significantly decreased in rabbits.

关 键 词：昆仑雪菊 萃取部位 家兔 降压筛选 

分 类 号：R285.5[医药卫生—中药学]