单纯微波消融及其联合无水酒精注射治疗原发性肝癌的疗效分析  

Curative effects of microwave ablation alone or combined with percutaneous ethanol injection in treatment of primary hepatocellular carcinoma: a comparative analysis

作　　者：沈裕厚[1] 谢振斌[1] 岳爱民[1] 赵宏峰[1] 魏齐栋[1] 尹宏达[1] 

机构地区：[1]河南省新乡市中心医院肿瘤外科,河南新乡453000

出　　处：《中国医药科学》2016年第5期26-29,33,共5页China Medicine And Pharmacy

摘　　要：目的回顾性分析微波消融（MWA）联合无水酒精注射（PEI）治疗与单纯微波消融治疗原发性肝癌的近期疗效及远期生存率。方法选取新乡市中心医院2009年5月~2012年5月进行的108例行微波消融治疗肝癌患者的临床资料。108例中45例行PEI联合MWA,63例行单纯MWA术。比较两组肿瘤完全消融率、复发率及术后1、2、3年生存率等情况。结果 PEI联合MWA组肿瘤完全消融率91.1%（41/45）,明显高于单纯MWA组的82.5%（52/63）,差异有统计学意义（P〈0.05）。PEI联合MWA组及单纯MWA组术后3个月、6个月、9个月、1年、2年局部复发率分别为23.3%、30.8%、70.2%、85.5%、95.8%及9.8%、18.4%、54.7%、74.1%、80.2%,差异有统计学意义（P〈0.05）。PEI联合MWA组及单纯MWA组术后6个月、1年、2年、3年总生存率分别为98.6%、90.5%、79.1%、68.2%及90.3%、81.9%、65.5%、50.3%,差异有统计学意义（P〈0.05）。结论 MWA联合PEI与单纯MWA治疗相比,对于肿瘤局部控制可取得更好的疗效,显著提高了肿瘤完全消融率,降低患者局部复发率,延长患者生存期,是一种更安全、有效的治疗方法。Objective To retrospectively analyze the short-term curative effect and long-term survival rates of microwave ablation（MWA） alone or combined with percutaneous ethanol injection（PEI） in the treatment of primary hepatocellular carcinoma. Methods Clinical data of 108 patients with hepatocellular carcinoma who were received MWA in Xinxiang Central Hospital from May 2009 to May 2012 were selected. In 108 patients, there were 45 cases of PEI combined with MWA and 63 cases of MWA alone. The complete ablation rates, recurrence rates, survival rates of 1, 2, 3 years after operation of the two groups were compared. Results The complete ablation rates of PEI combined with MWA group was 91.1%（41/45）, significantly higher than that of the MWA alone group 82.5%（52/63）. The difference had statistical significance（P〈0.05）. Local recurrence rates of 3 months, 6 months, 9 months, 1year and 2years after operation of the PEI combined with MWA group and the MWA alone group were 23.3%, 30.8%, 70.2%, 85.5%, 95.8% and 9.8%, 18.4%, 54.7%, 74.1%, 80.2% respectively. Differences had statistical significance（P〈0.05）. Total survival rates of 6 months, 1year, 2 years and 3 years of the PEI combined with MWA group and the MWA alone group were 98.6%, 90.5%, 79.1%, 68.2% and 81.9%, 50.3%, 65.5%, 50.3% respectively（P〈0.05）. Conclusion Compared with MWA alone, MWA combined with PEI has a better curative effect in locally controlling tumor. And it significantly improve complete ablation rates, reduce local recurrence rate and prolong the survival time of patients, which is a safe and effective treatment.

关 键 词：肝细胞癌 微波消融 无水酒精注射 局部复发率 总生存率 

分 类 号：R735.7[医药卫生—肿瘤]