诺维本加顺铂一线治疗老年复发转移性三阴性乳腺癌的临床分析  

The clinical analysis of navelbine combined cisplatin as the first line therapy in the treatment of elderly patients with recurrent and metastatic triple negative breast cancer

作　　者：黄喜文[1] 邹小芳[1] 吴国武[1] 黎佳全[1] 

机构地区：[1]广东省梅州市人民医院化疗2科,广东梅州514031

出　　处：《中国医药科学》2016年第5期104-106,118,共4页China Medicine And Pharmacy

摘　　要：目的观察诺维本加顺铂一线治疗老年复发转移性三阴性乳腺癌的安全性和临床疗效。方法选取2012年4月~2014年4月我院收治并诊断为老年复发转移性三阴性乳腺癌的患者72例,采用随机数字表法,将其分为A组和B组,每组36例。A组采用诺维本联合顺铂治疗,B组采用诺维本联合卡培他滨治疗,经治疗后,比较A组和B组的临床总有效率、无进展生存期（progression free survival,PFS）和不良反应的发生情况。结果两组患者接受治疗后,A组的总有效率为58.2%,B组的总有效率为27.7%,A组疗效显著优于B组,差异有统计学意义（P〈0.05）。A组PFS为（7.74±0.41）个月,B组PFS为（5.18±0.35）个月,A组优于B组,差异有统计学意义（P〈0.05）。不良反应发生情况：A组恶心、呕吐的发生率为38.8%,手足综合征的发生率为5.5%;B组恶心、呕吐的发生率为13.8%,手足综合征的发生率为41.6%,两组比较,差异均有统计学意义（均P〈0.05）;而对于白细胞下降、血小板下降、口腔炎、肾损害不良反应等方面,两组比较,差异无统计学意义（均P〉0.05）。结论诺维本加顺铂一线治疗治疗老年复发转移性三阴性乳腺癌的总有效率较高,PFS较好,安全性较好,值得推广应用。Objective To observe Navelbine plus cisplatin safety and clinical efficacy in elderly recurrent and metastatic triple negative breast cancer. Methods From April 2012 to April 2014 in our hospital and diagnosed elderly patients with metastatic triple-negative breast cancer in 72 cases, the use of random number table was divided into Group A and Group B, n=36 example.A group with vinorelbine plus cisplatin treatment, group B Navelbine plus capecitabine treatment, after treatment, clinical comparison group A and group B total efficiency, the progression free survival（PFS） and the occurrence of adverse reactions. Results The two groups of patients after treatment, the total effective rate in group A 58.2%, total effective rate of group B 27.7%, A group was significantly better than group B, the difference was statistically significant（P〈0.05）. The PFS in group A was（7.74±0.41） months, while in group B the PFS was（5.18±0.35） months, The PFS in group A was better than group B, the difference was statistically significant（P〈0.05）. Adverse events： A group of nausea, vomiting rate of 38.8%, the incidence of hand-foot syndrome was 5.5%; group B, nausea, vomiting rate of 13.8%, the incidence of hand-foot syndrome was 41.6%, two group, the differences were statistically significant（P〈0.05）; while for leucopenia, thrombocytopenia, stomatitis, kidney damage and other adverse aspects of the two groups, the difference was not statistically significant（P〈0.05）. Conclusion Navelbine plus cisplatin therapy treatment of senile metastatic triple negative breast cancer have a higher overall efficiency, the median PFS is better, better security, should be widely applied.

关 键 词：诺维本 顺铂 老年 复发转移性三阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]