Leojaponic acids A and B, two new homologous terpenoids, isolated from Leonurus japonicus  

作　　者：WU Han-Kui MAO Yan-Jun SUN Shan-Shan XU Zhi-Yong MA Ya CAO Jin-Xia QI He WU Zhi-Fu LI Gang YANG Wei-Hua 

机构地区：[1]College of Chemistry and Chemical Engineering, Anyang Normal University [2]Institute of Analytical Science, Northwest University [3]Institute of Cotton Research, Chinese Academy of Agriculture Sciences

出　　处：《Chinese Journal of Natural Medicines》2016年第4期303-307,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(U1304825,201302004);the National Key Technology R&D Program(2012BAD36B01-02)

摘　　要：The present study aimed at isolation and purification of the bioactive terpenoids from the herb of Leonurus japonicus by chromatographic separations such as silica gel, sephadex LH-20 and C18 reversed phase silica gel, as well as preparative HPLC. As a result, leojaponic acids A(1, C_(17)H_(24)O_4) and B(2, C_(18)H_(26)O_4), two homologous terpenoids, together with(-)-loliolide(3), 1-(3-ethylphenyl) ethane-1, 2-diol(4) and dibutyl phthalate(5), were isolated from the Et OH extract of L. japonicus. All the chemical structures of the isolates were elucidated on the basis of 1D and 2D NMR analyses. Compounds 1 and 2 were new terpenoids, and Compounds 3 and 4 were isolated and identified for the first time from this plant. In addition, the a-glucosidase and tyrosinase inhibitory activity of the new compounds were evaluated.The present study aimed at isolation and purification of the bioactive terpenoids from the herb of Leonurusjaponicus by chromatographic separations such as silica gel, sephadex LH-20 and C18 reversed phase silica gel, as well as preparative HPLC. As a result, leojaponic acids A （1, C17H24O4） and B （2, C18H26O4）, tWO homologous terpenoids, together with （-）-loliolide （3）, 1-（3-ethylphenyl） ethane-1, 2-diol （4） and dibutyl phthalate （5）, were isolated from the EtOH extract ofL. japonicus. All the chemical structures of the isolates were elucidated on the basis of 1D and 2D NMR analyses. Compounds 1 and 2 were new terpenoids, and Compounds 3 and 4 were isolated and identified for the first time from this plant. In addition, the a-glucosidase and tyrosinase inhibitory activity of the new compounds were evaluated.

关 键 词：Leonurus japonicus Leojaponic acid TERPENOID 

分 类 号：R284[医药卫生—中药学]