Bmi-1蛋白在结直肠癌组织中表达的Meta分析  

A Meta Analysis and System Review of Bmi-1 Protein Expression in Colorectal Cancer

作　　者：陈志新[1] 金卉[1] 黄杰安[1] 

机构地区：[1]广西医科大学第一附属医院,广西南宁530021

出　　处：《中国医学创新》2016年第11期108-111,共4页Medical Innovation of China

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2012144)

摘　　要：目的:探讨Bmi-1蛋白的表达与结直肠癌的关系。方法:按照纳入与排除标准选择独立病例对照研究,计算机检索Cochrane、Pub Med、CNKI、万方等数据库,辅以手工检索,收集2004年至今的相关文献,所有数据统计应用Rev-Man 5.2分析软件进行Meta分析。结果:共检索116篇文献,最终纳入文献8篇,累计结直肠癌667例,对照组635例。Meta分析结果示Bmi-1在结直肠癌组中的表达水平高于对照组(P<0.000 01);Bmi-1表达与结直肠癌分化程度、淋巴结转移、TNM分期、Dukes分期、远处转移均有关,相关性有统计学意义(P<0.01),但与患者年龄、性别、浸润深度、肿瘤大小相关性均无统计学意义(P>0.05)。结论:Bmi-1蛋白的表达水平可能成为结直肠癌早期诊断、预后判断及疗效观察的新指标。Objective：To study the relation between Bmi-1 protein expression and colorectal cancer.Method：Independent case-control studies were chosen from the gathered relevant literatures since 2004 by computer retrieval in database of Cochrane,Pub Med,CNKI,Wanfang supplemented with manual retrieval according to the inclusion and exclusion criteria,which were conducted statistical Meta analysis by Rev-Man 5.2 analysis software.Result：Eventually 8 references was included from 116 literatures,which accumulated 667 cases of colorectal cancer and 635 cases of the control group.Meta analysis results showed the expression level of Bmi-1 in colorectal cancer group was higher than the control group,the correlation was statistic significant（P〈0.000 01）.The expression of Bmi-1 had influence on colorectal cancer with differentiation,lymph node metastasis,TNM staging,Dukes stage,distant metastasis（P〈0.01）,but had no correlation with age,gender,infiltration depth and tumor size（P〉0.05）.Conclusion：The expression level of Bmi-1 protein may be a new indicator for the early diagnosis,prognostic and curative effect observation on colorectal cancer.

关 键 词：BMI-1 结直肠癌 META分析 

分 类 号：R735.34[医药卫生—肿瘤]