经颅直流电刺激小脑对遗忘型轻度认知功能障碍患者言语工作记忆能力的影响  

The effects of transcranial direct current stimulation on the verbal working memory of amnesic patients with mild cognitive impairment

作　　者：胡荣亮[1,3] 陈卓铭[1] 冯尚武 陈颂玲[3] 王红[1] 

机构地区：[1]暨南大学附属第一医院康复医学科,广州510630 [2]江门市残联康复医院 [3]中山大学附属江门医院神经康复科

出　　处：《中华物理医学与康复杂志》2016年第4期267-271,共5页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：国家自然科学基金资助项目（81372113）;国家科技部“十二五”科技支撑计划项目（2013BA110801）

摘　　要：目的探讨经颅直流电刺激（tDCS）阳极刺激右侧小脑对遗忘型轻度认知功能障碍（aMCI）患者言语工作记忆能力的影响。方法采用随机数字表法将39例aMCI患者分为观察组及对照组。观察组患者采用tDCS阳极刺激右侧小脑部位，电刺激强度为1．2mA，每次治疗持续20rain，每天治疗1次；对照组患者则给予tDCS伪刺激，每次治疗持续20min，每天治疗1次。于治疗前、治疗5d后采用数字广度测验及其他认知控制任务测验（如阅读干扰词汇测试、感觉．运动测试、手指敲击测试）对2组患者言语工作记忆能力改善情况进行评定。结果治疗后发现观察组患者顺背数字广度成绩[（5．5±0．2）个]、倒背数字广度成绩[（4．7±0．2）个]均较治疗前及对照组明显提高（P〈0．05）；对照组患者治疗后其倒背数字广度成绩[（4．1±0．3）个]较治疗前明显提高，但顺背数字广度成绩[（4．5±0．2）个]较治疗前无明显改善（P〉0．05）；2组患者治疗前、后其阅读干扰词汇测试、感觉一运动测试、手指敲击测试成绩组间及组内比较，差异均无统计学意义（P〉0．05）。结论tDCS阳极刺激右侧小脑可改善aMCI患者言语工作记忆能力，其确切作用机制还有待进一步探讨。Objective To investigate if anodal transcranial direct current stimulation （atDCS） of the right cerebellum improves verbal working memory in amnesic persons with mild cognitive impairment （aMCI）. Methods Thirty-nine aMCI were randomly divided into an observation and a control group using a random number table. The observation group was given atDCS at 1.2 mA for 20 minutes every day for 5 days, while the control group was provid- ed with fake atDCS in the same way. Before and after the treatment, both groups were tested using forward and back- ward digit spans, word reading, visually cued sensorimotor tests and finger tapping. Results After the treatment, the forward and backward digit spans of the observation group had improved significantly compared with before the treatment and with the control group＇s improvements. Significant improvement was observed in the average backward digit span of the control group, but not in their forward digit span after the treatment. No significant differences between the two groups were observed in the other measurements before or after the treatment. Conclusion Direct current stimulation of the cerebellum may improve the verbal working memory deficits of aMCI. Further research should be conducted to find the mechanism.

关 键 词：经颅直流电刺激 遗忘型轻度认知功能障碍 言语工作记忆 小脑 数字广度 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R454.1[医药卫生—临床医学]