真核翻译起始因子4G与肿瘤  

Role of eukaryotic translation initiation factor 4G in tumor

作　　者：张思[1] 黄楠[1] 潘霞[1] 臧婧蕾 管馨馨 张建华[1] 刘柳成[1] 雷小勇[1] 

机构地区：[1]南华大学药物药理研究所,衡阳421000

出　　处：《生理学报》2016年第2期207-214,共8页Acta Physiologica Sinica

基　　金：国家自然科学基金(No.81372579);湖南省十二五重点学科建设项目;湖南省分子靶标新药研究协同创新中心[湘教通(2014)405号]资助

摘　　要：真核翻译起始因子4G(eukaryotic translation initiation factor 4G,eIF4G)是eIF4F复合物中的一种"支架蛋白",在蛋白质合成的起始阶段中发挥重要的调控作用。近年来研究表明,eIF4G的两个亚型eIF4G1和eIF4G2跟许多恶性肿瘤的调控有密切关系,相对于相应的正常组织,eIF4G1在乳腺癌、宫颈癌、鼻咽癌、肺鳞状细胞癌、前列腺癌等恶性肿瘤中表达明显增高;而eIF4G2在弥漫性大B细胞淋巴瘤、急性髓细胞性白血病、膀胱移行细胞癌也有明显的差异性表达。因此,本文主要总结eIF4G、eIF4G1和eIF4G2的表达情况对肿瘤发生、发展及预后的影响,为肿瘤早期预测、靶向治疗及预后提供更好的理论依据。Eukaryotic translation initiation factor 4G（eIF4G） is a scaffold component of eukaryotic translation initiation factor 4F（eIF4F） complex, which takes principal part in the initiating of protein synthesis. Both two subtypes（eIF4G1 and eIF4G2） of eIF4 G were found to be closely related with various tumors. The eIF4G1 expression is significantly up-regulated in breast cancer, cervical cancer, nasopharyngeal carcinoma, lung squamous cell carcinoma, prostatic carcinoma and other malignant tumors, compared with those in adjacent tissues; and the eIF4G2 is obviously over-expressed in diffuse large B cell lymphoma and acute myeloid leukemia, but low-expressed in bladder transitional cell carcinoma. This paper reviews the progress in the study of the role of eIF4 G in tumor genesis, development, diagnosis and prognosis.

关 键 词：真核翻译起始因子4G(eIF4G) eIF4G1 eIF4G2 肿瘤 

分 类 号：R73-3[医药卫生—肿瘤]