Omi/HtrA2与XIAP在人乳腺癌中的表达及意义  

Expression of Omi/HtrA2 and XIAP in human breast cancer and their significance

作　　者：张苏园 杨永福[1] 郑洪[1] 黄佳佳[1] 黎成芳[1] 

机构地区：[1]遵义医学院附属医院病理科,贵州遵义563003

出　　处：《诊断病理学杂志》2016年第4期276-278,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的研究通过检测Omi/Htr A2与XIAP在乳腺癌组织中的表达,探讨其相互关系。方法采用免疫组化法检测40例乳腺癌、10例乳腺纤维腺瘤组织中Omi/Htr A与XIAP的表达情况。结果在乳腺浸润性导管癌中,Omi/Htr A2与XIAP的表达高于乳腺纤维腺瘤(P<0.05),且二者的表达呈负相关。Omi/Htr A2与XIAP的表达分别与临床分期有关,与患者年龄和有/无淋巴结转移无关。结论 Omi/Htr A2与XIAP在乳腺浸润性导管癌的发生、发展中可能扮演重要角色。To detect the expression of XIAP and Omi / Htr A2 in breast cancer,and to explore their mutual relationship.Methods XIAP and Omi / Htr A expression was detected in 40 cases of breast cancers and 10 breast fibroadenomas by immunohistochemistry. Results The expression of Omi / Htr A2 and XIAP protein in the breast invasive ductal carcinoma was higher than that in breast fibroadenoma（ P〈0. 05）,and the expression of Omi / Htr A2 and XIAP was related with clinical stage,but not with the patient ＇s age and lymph node metastasis. Conclusion The expression of Omi / Htr A2 and XIAP might be related to the pathogenesis of invasive ductal carcinoma of the breast.

关 键 词：OMI/HTRA2 XIAP MCF-7 乳腺浸润性导管癌 乳腺纤维腺瘤 

分 类 号：R737.9[医药卫生—肿瘤]