LIMK1/Cofilin信号通路与肿瘤的研究进展  

Progress of LIMK1/Cofilin signal pathway in tumor

作　　者：吴南芳 张琍[1] 

机构地区：[1]南华大学第二附属医院,湖南衡阳421001

出　　处：《微生物学免疫学进展》2016年第1期72-75,共4页Progress In Microbiology and Immunology

基　　金：国家自然科学基金资助项目(No.81372378)

摘　　要：LIMK1是一种存在于真核生物中的丝氨酸/苏氨酸蛋白激酶,Cofilin是存在于真核生物中的一种低相对分子质量的肌动蛋白结合蛋白。LIMK1磷酸化并使Cofilin失活,磷酸化Cofilin的肌动蛋白结合活性降低,从而导致肌动蛋白聚合并使其稳定。LIMK1/Cofilin信号通路调节细胞骨架蛋白,并且参与微丝肌动蛋白应力纤维和黏附斑形成,进而调节微丝骨架系统影响肿瘤细胞的转移。根据目前国内外的各项研究成果,就LIMK1/Cofilin信号通路与肿瘤的研究进展予以综述。LIMK1 is a kind of serine / threonine protein kinase which Exists in eukaryotes. Cofilin is a low molecular weight actin-binding protein which exists in eukaryotes. LIMK1 phosphorylates and inactivates cofilin,the actin-binding activity of phospho-cofilin is reduced,resulting in actin polymerization and stabilization LIMK1 / Cofilin signaling pathway regulates cytoskeletal proteins,anticipating in filamentous actin stress fibers and adhesion plaque formation,thereby regulating the actin cytoskeleton and affecting metastasis of tumor cells. This paper reviews the progress in this aspect of research,and here giving some possible suggestions about LIMK1 / Cofilin pathway in tumor progress research.

关 键 词：LIMK1/Cofilin信号通路 磷酸化 失活 肿瘤 综述 

分 类 号：R730.2[医药卫生—肿瘤]