干烤法测定C群脑膜炎球菌多糖原液固体总量的不确定度评定  

Evaluation of uncertainty in dry weight of group C meningococcal polysaccharide bulk by dry baking method

作　　者：张玲玲[1] 刘晓凡[1] 傅元欣[1] 冯潇[1] 魏然[1] 朱莉萍[1] 

机构地区：[1]兰州生物制品研究所有限责任公司质量检定室甘肃省疫苗工程技术研究中心,甘肃兰州730046

出　　处：《微生物学免疫学进展》2016年第2期35-39,共5页Progress In Microbiology and Immunology

摘　　要：目的建立干烤法测定C群脑膜炎球菌多糖原液固体总量的不确定度分析方法。方法分析C群脑膜炎球菌多糖原液固体总量测定过程中引入的不确定度,并对各个不确定度的分量进行评估。结果由各分量不确定度计算合成不确定度,最终给出测定结果在95%置信区间的扩展不确定度。结论 C群脑膜炎球菌多糖原液固体总量测量不确定度主要由取样及干燥过程引入,在试验中须严格控制以减小不确定度。Objective To set up an analysis method in evaluation of the uncertainty for group C meningococcal polysaccharide bulk by dry baking method. Methods Factors influencing uncertainty were analyzed and evaluated from procedures of dry weight of group C meningococcal polysaccharide bulk. Results Each component related uncertainty was calculated,then the combined uncertainty was obtained by synthetizing the uncertainties of various component variables and the extended uncertainty was obtained in 95% confidence intervals. Conclusion The uncertainty in dry weight of group C meningococcal polysaccharide bulk was mainly caused by the process of sampling and drying,so it should be strictly controlled to reduce the uncertainty in experiment.

关 键 词：C群脑膜炎球菌多糖原液 固体总量 不确定度 

分 类 号：R378.15[医药卫生—病原生物学]