PPARγ受体与消化道肿瘤相关性的研究进展  

Progress of correlation between PPARγ receptor and digestive tract tumor

作　　者：高菲[1] 张琍[1] 

机构地区：[1]南华大学第二附属医院消化内科,湖南衡阳421001

出　　处：《微生物学免疫学进展》2016年第2期79-83,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金资助项目(N0.81372378)

摘　　要：过氧化物酶体增殖物激活受体-γ(PPARγ)是由配体激活的一类核转录因子,属于II型核受体超家族成员之一。经研究发现,PPARγ在多种肿瘤组织中均有所表达,而且它在调控细胞分化、诱导细胞凋亡和抑制细胞增殖中发挥重要的转录调节作用。激活后的PPARγ可以调控多种核内靶基因的表达,抑制肿瘤细胞的形成、生长与增殖等,与消化道肿瘤的发生、发展及预后有着密切的关系。Peroxisome proliferator-activated receptor-γ（ PPARγ） is a kind of ligand-activated nuclear transcription factor.It is one of members of type II nuclear receptor superfamily. The researches found that PPARγ has expressed in various tumor tissues,and it plays an important role on the regulation of cell differentiation,induction of apoptosis,inhibition of cell proliferation and transcriptional regulation. Activated PPARγ can regulate the expression of many genes in the nucleus,and inhibit tumor cell growth and proliferation,etc. PPARγ is closely related to occurrence development and prognosis of gastrointestinal cancer.

关 键 词：过氧化物酶体增殖物激活受体-Γ 消化道 肿瘤 相关性 

分 类 号：R735[医药卫生—肿瘤]