木棉花总黄酮降血脂作用及其机制研究  

Antihyperlipidemic effects and mechanism of total flavonoids of Gossampinus malabarica Merr

作　　者：卢秋玉[1] 陈晓宇[1] 申庆荣[1] 梁韬[2] 梁霜[3] 唐爱存[3] 

机构地区：[1]广西壮族自治区人民医院药学部,南宁530021 [2]广西医科大学附属口腔医院,南宁530021 [3]广西中医药大学第一附属医院药学部,南宁530023

出　　处：《中药药理与临床》2016年第1期88-90,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：广西壮族自治区卫生计生委研究项目(No.Z2015481)

摘　　要：目的:研究木棉花总黄酮对高脂血症大鼠血脂的影响。方法:雄性SD大鼠随机分为空白组、模型组、阳性对照阿托伐他汀钙片组(5 mg/kg)、木棉花总黄酮组(100 mg/kg,200 mg/kg,400 mg/kg)。除空白组外,其余组每天灌胃给予10 ml/kg高脂乳剂,一周后,在每天灌胃高脂乳剂的基础上,每日灌胃给药1次,连续给药30 d,空白组与模型组每天灌服等体积的生理盐水。测定大鼠血清中总甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平和大鼠血清载脂蛋白AⅠ(apoAⅠ)和载脂蛋白B100(apoB100)的含量,并检测大鼠全血黏度、血浆黏度、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血活酶时间(TT)和纤维蛋白原含量(FIB)。结果:与模型组比较,木棉花总黄酮(100,200,400 mg/kg)能降低高脂血症大鼠血清中TG、TC、LDL-C和apoB100的含量,升高HDL-C和apoAⅠ的含量,降低全血黏度和血浆黏度,同时能显著性延长PT、APTT和TT及降低FIB。结论:木棉花总黄酮具有显著降血脂作用,其机制可能与调节载脂蛋白和改善血液流变学有关。Objective： To investigate the antiatheroscloresis effects of total flavonoids of Gossampinus malabarica Merr（ TFG） on hyperlipidemia rats. Methods： Healthy male SD rats were divided into six groups randomly,10 rats in each group,blank group,model group,positive control group（ 5mg / kg）,total flavonoids of Gossampinus malabarica Merr groups（ 100 mg / kg,200 mg / kg,400 mg / kg）,respectively,except the blank group,the rest of the group were treated with high fat emulsion through gavage of 10 ml / kg,one week later,based on the administration of fat emulsion daily,then the experimental rats were administrated with drugs by ig for 30 days,and once a day,blank group and the model group were given normal saline. The levels of TG,TC,LDL-C,HDL-C,apo AⅠ,apo B100 and the whole blood viscosity and plasma viscosity,and PT,APTT,TT,FIB were measured. Results： Compared with the model group,total flavonoids of Gossampinus malabarica Merr groups（ 100 mg / kg,200 mg / kg,400 mg / kg） could reduce the levels of TG,TC,LDL-C and apo B100,and elevated the levels of HDL-C and apo AⅠsignificantly（ P 0. 05 or P 0. 01）,and reduce the whole blood viscosity and plasma viscosity（ P 0. 05 or P 0. 01）,meanwhile,TFG could also extend the PT,APTT and TT,however,TFG could reduce the FIB. Conclusion： TFG shows remarkable effects on antihyperliposis in the hyperlipemia rats,the mechanism may be related to regulating apolipoprotein and improving hemorrheology.

关 键 词：木棉花总黄酮 高脂血症 降血脂 载脂蛋白 血液流变学 

分 类 号：R285.5[医药卫生—中药学]