贵州省人民医院癫痫儿童流行病学调查  

Epidemiological investigation of children with epilepsy in the people's hospital of Guizhou province

作　　者：胡晓[1] 潘炜[1] 王建怡[1] 

机构地区：[1]贵州省人民医院神经内科,贵阳550002

出　　处：《临床神经病学杂志》2016年第2期90-94,共5页Journal of Clinical Neurology

基　　金：国家自然青年科学基金项目(8140051593);贵州省科技厅攻关项目[黔科合SY字(2012)3143号];贵州省联合基金项目[黔科合J字(2011)228l号]

摘　　要：目的调查贵州省人民医院癫痫儿童流行病学特点。方法对贵州省人民医院确诊的14岁以内癫痫患儿860例进行临床资料采集。随访患儿1年,根据治疗后发作频率的改变来进行疗效评价。对结果进行统计学分析。结果贵州省人民医院癫痫患儿临床特点为：以1-3岁幼儿为主;男性患儿较多;新生儿窒息、胎儿窘迫是导致儿童癫痫发作的主要围产期诱因,5.26%患儿有癫痫家族史。患儿中农村患儿占57.23%,其与城市患儿存在统计学差异的相关指标为：发病年龄、生产史、生产方式、围产期发生胎儿宫内窘迫及母孕期服药史（P〈0.05-0.01）。治疗依从性差是影响癫痫患儿预后的危险因素（OR=0.06,95%CI：0.023-0.152,P〈0.01）。结论贵州省人民医院癫痫儿童以1-3岁幼儿为主,男性患儿及农村患儿较多。良好的服药依从性是影响其预后的关键因素。改善农村生产条件、加强孕期健康宣教可能减少农村儿童癫痫发生率。Objective To investigate the epidemiological characteristics of children with epilepsy in the people＇s hospital of Guizhou province. Methods The clinical data of 860 children（ below 14 years old） with epilepsy diagnosed by the people＇s hospital of Guizhou province was collected. After followed-by for 1 year,the curative effect was evaluated according to the change of seizure frequency after treatment. And the results were statistically analyzed. Results The clinical characteristics of children in the people＇s hospital of Guizhou province showed main part of children were 1- 3 years old,and most of them were male; neonatal asphyxia and fetal distress were the leading perinatal causes in children with epilepsy,5. 26% children had family history of epilepsy. The result showed that 57. 23% children came from rural areas,and the related indexes which had significant differences in children age,history of birth,birth method,fetal distress function,elderly primiparous and pregnancy medication history between rural and city children（ P〈0. 05- 0. 01）. Poor compliance of therapy was the risk factor of prognosis in children with epilepsy（ OR = 0. 06,95% CI： 0. 023- 0. 152,P〈0. 01）. Conclusions Children in the people＇s hospital of Guizhou province are mainly 1- 3 years old,and most of them were male and rural. Good medication compliance is the key factor to affect the prognosis. Improvement of rural production conditions and enhanced health education during pregnancy may reduce the incidence of rural children with epilepsy.

关 键 词：儿童 癫痫 流行病学调查 农村 

分 类 号：R742.1[医药卫生—神经病学与精神病学]