Notch信号通路在遗传性色素障碍性皮肤病的研究进展  

Notch signaling in hereditary pigmentary disorders

作　　者：王臻[1] 李明[1] 姚志荣[1] 

机构地区：[1]上海交通大学医学院附属新华医院皮肤科,200092

出　　处：《国际皮肤性病学杂志》2016年第1期57-59,共3页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81472867）;上海交通大学医学院院基金（13XJ10023）

摘　　要：色素障碍性皮肤病主要由黑素细胞功能障碍或数目异常所致,严重影响皮肤外观.近期一系列研究报道,Notch信号通路组成部分功能的异常或缺失与人类遗传性色素障碍性皮肤疾病发病相关.Notch信号通路是一条高度保守的调控细胞分化增殖凋亡的信号传导途径,但其如何导致色素异常的致病机制尚不明确.探讨Notch信号通路在遗传性色素障碍性皮肤病的研究进展,为理解遗传因素在黑素细胞生长发育和功能中发挥的作用提供了新视野.Pigmentary disorders, a class of common diseases in dermatology caused by abnormalities in melanocyte function or count, severely affects skin appearance of patients.Recently, a series of reports have suggested that hereditary pigmentary disorders are associated with the abnormality in or loss of function of the highly conserved Notch signaling pathway, which is important for the regulation of cell differentiation, proliferation and apoptosis.However, how the Notch signaling pathway causes aberrant pigmentation remains unclear.This article reviews advances in the Notch signaling pathway in hereditary pigmentary disorders, which may provide new insights into the roles of genetic factors in melanocyte development and function.

关 键 词：皮肤疾病 遗传性 色素沉着异常 黑素细胞 遗传 NOTCH信号通路 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]