转化生长因子-β3与纤维连接蛋白在子宫肌瘤及子宫肌层内的表达水平与生物学意义  被引量:11

Expression and biological significance oftransforming growth factor-β3 and fibronectin in uterine myoma and uterine muscle layer

在线阅读下载全文

作  者:潘伟[1] 汪海霞[2] 刘霞[2] 

机构地区:[1]黄石市中心医院妇科门诊,湖北黄石435000 [2]黄石市爱康医院产科,湖北黄石435000

出  处:《中国性科学》2016年第4期60-62,共3页Chinese Journal of Human Sexuality

摘  要:目的:探讨转化生长因子(TGF)-β3与纤维连接蛋白(FN)在绝经或未绝经妇女子宫肌瘤及子宫肌层中表达的水平变化及其意义。方法:采用免疫组化法(SP)检测40例绝经后子宫肌瘤妇女(绝经组)、40例未绝经子宫肌瘤妇女(未绝经组)肌瘤组织及肌壁组织中的TGF-β3、FN的表达差异,同时将绝经组妇女根据肌瘤是否发生萎缩分为萎缩组(17例)、未萎缩组(23例)并进行上述指标的比较。结果:绝经组的肌瘤组织、肌壁组织中的TGF-β3表达评分分别为(3.11±0.78)分、(1.85±0.69)分均显著的低于未绝经妇女的(3.98±0.67)分、(2.31±0.82)分(P<0.05);两组妇女肌瘤组织和肌壁组织中的FN表达评分差异不显著(P>0.05)。子宫肌瘤萎缩和未萎缩患者的子宫肌瘤组织、肌壁组织中TGF-β3、FN表达在两组间差异均不显著(P>0.05),萎缩组和未萎缩组的肌瘤组织TGF-β3表达分别为(2.90±0.65)分、(3.32±0.74)分均显著的高于本组肌壁组织中的(1.85±0.67)分、(2.25±0.61)分(P<0.05);两组肌瘤和肌壁组织中的FN表达差异不显著(P>0.05)。结论:TGF-β3表达可能与患者绝经前后的激素水平改变有关。Objectives:To discuss the expression and biological significance of transforming growth factor-β3 and fibronectin in uterine myoma and uterine muscle layer.Methods:Using immunohistochemical method (SP),40 cases of postmenopausal uterine leiomyoma (postmenopausal group) and 40 cases of premenopausal uterine leiomyoma (premenopausal group) were selected.Different expression of TGF-beta-3 and NF on leiomyoma tissue and muscle tissues were detected.At the same time,postmenopausal group was divided into atrophy group (17 cases) and non-atrophy group (23 cases).The above indexes of the two groups were compared.Results:The TGF-beta-3 expression scores of premenopausal group in muscle tissue and leiomyoma wall were (3.11 ±0.78) and (1.85 ± 0.69) points,which were significantly lower than these of premenopausal group (3.98 ±0.67,2.31 ± 0.82) (P〈0.05);FN expression score of two groups in leiomyoma tissue and muscle tissues had no significant difference (P〉0.05).TGF-beta-3 and FN expression of atrophy group and non-atrophy group in uterine fibroids and uterine tissues had no significant difference (P〉0.05).TGF-beta-3 expression of atrophy group and non-atrophy group in uterine fibroids were (2.90 ± 0.65) and (3.32 ± 0.74),which were both significantly higher than these in uterine tissues of (1.85 ± 0.67) and (2.25 ± 0.61) (P〈0.05);FN expression of the two group in fibroids and muscle tissues did not show significant difference (P〉0.05).Conclusion:TGF-beta-3 expression of premenopausal patients is significantly higher than that of postmenopausal patients;TGF-beta-3 expression of atrophic group and non-atrophy patients in leiomyoma is higher than that in muscle wall tissue,without significant difference.TGF-beta-3 expression may be associated with hormone level changes in postmenopausal patients.

关 键 词:转化生长因子-Β3 纤维连接蛋白 绝经 子宫肌瘤 子宫肌层 

分 类 号:R737.33[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象