首发男性抑郁症患者血清性激素水平检测研究  

Levels of serum sex hormone in male patients with first-episode depression

作　　者：严辞 苑杰 严洪琪 

机构地区：[1]华北理工大学心理学院,河北唐山063000 [2]华北理工大学精神卫生研究所,河北唐山063000 [3]哈尔滨市第一专科医院,哈尔滨150000

出　　处：《中国性科学》2016年第4期145-147,共3页Chinese Journal of Human Sexuality

摘　　要：目的:探讨首发男性抑郁症患者血清性激素水平的变化及与临床症状的相关性。方法:30例首发男性抑郁症患者和30例正常男性对照为研究对象。采用放射免疫法,检测所有入组人群血清泌乳素(PRL)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)和雌二醇(E_2)的含量,并评定汉密尔顿抑郁量表24项版本(HAMD24)的总分及各项因子分。结果:首发男性抑郁症患者血清T、E_2水平与健康男性对照组相比有明显下降(P<0.05),PRL、LH和FSH水平与健康男性对照组相比无明显差异。相关分析显示,首发男性抑郁症患者血清T水平与认知及睡眠障碍呈负相关(r=-0.548,P<0.05、r=-0.541,P<0.05);患者血清E_2水平与HAMD24总分及睡眠障碍呈负相关(r=-0.434,P<0.05、r=-0.418,P<0.05)。结论:男性抑郁症患者存在性激素代谢紊乱的现象,其特点是血清T、E_2水平下降,并且患者的血清T和E_2水平与某些临床症状存在相关性。Objectives：To investigate the correlation between the changes of serum sex hormone levels in male patients with first-episode depression and clinical symptoms.Methods：30 male patients with first-episode depression and 30 normal male were chosen as the subject of research.The level of serum prolactin （PRL）,luteinizing hormone （L H）,follicle stimulating hormone （FSH）,testosterone （T） and estradiol （E2） were measured by radioimmunoassay method,and the total score and all factor scores of Hamilton Depression Scale-24 （HAMD24）were assessed by experts.Results：Compared with healthy male,the levels of serum T and E2 in male patients with first-episode depression were obviously decreased （P〈0.05）.However,there was no significant difference in levels of PRL,LH,and FSH.Correlation analysis showed that the serum level of T was negatively correlated with cognitive scores and sleep scores in patients with first-episode depression （r =-0.548,P〈0.05 、r =-0.541,P〈0.05）;The level of serum E2 was also negatively correlated with the total score of HAMD24 and sleep disorders （r =-0.434,P〈0.05,r =-0.48,P〈0.05）.Conclusions：There is sex hormone metabolism in male patients with first-episode depression.It is characterized with the decline of levels of serum T and E2.In addition,there is certain correlation between levels of serum T and E2 in male patients with first-episode depression and some clinical symptoms.

关 键 词：男性 抑郁症 性激素 临床症状 相关性 

分 类 号：R749.41[医药卫生—神经病学与精神病学]