药物自我处置及症状自我监控与首发精神分裂症复发的相关性研究  

Influence of medication self-management and symptom self-monitoring on the relapse in patients with first-episode schizophrenia

作　　者：葛茂宏 孙红立[1] 王程辉[1] 

机构地区：[1]潍坊市精神卫生中心,山东潍坊262400

出　　处：《精神医学杂志》2016年第2期105-108,共4页Journal of Psychiatry

基　　金：山东省潍坊市卫生局科研计划项目(编号:2014年第091号)

摘　　要：目的探讨药物自我处置及症状自我监控对首发精神分裂症(FEP)患者复发的作用。方法将120例FEP患者随机分为研究组和对照组,药物治疗基础上,研究组接受药物自我处置和症状自我监控训练。于入组时、训练后第8周末和随访1年末采用阳性和阴性综合征量表(PANSS)、自知力与治疗态度问卷(ITAQ)、社会功能缺陷筛选量表(SDSS)、康复状态量表(MRSS)进行评定。结果 (1)随访结束时,两组复发率、再住院率及就业率存在显著性差异(P<0.01);(2)研究组第8周末PANSS、SDSS、MRSS评分较入组时降低(P<0.01),ITAQ评分较入组时升高(P<0.01);随访1年时SDSS评分较入组时降低(P<0.01);(3)对照组第8周末PANSS评分较入组时升高(P<0.01),随访1年ITAQ评分均较入组时降低(P<0.01),PANSS、SDSS评分较入组时升高(P<0.01),SDSS评分较第8周末升高(P<0.01);(4)两组随访1年PANSS、MRSS评分均较第8周末升高(P<0.01),ITAQ评分均较训练后第8周末降低(P<0.01),MRSS评分均较入组时升高(P<0.01)。研究组第8周末、随访1年PANSS、SDSS、MRSS评分均低于对照组(P<0.01),ITAQ评分高于对照组(P<0.01)。结论药物自我处置与症状自我监控可有效控制FEP患者精神症状,降低疾病复发率及患者再住院率,提高患者的社会功能。Objective To investigate the effect of medication self-management and symptom self-monitoring on the relapse in patients with first-episode schizophrenics（ FEP）. Methods 120 FEP patients were randomized into study group treated with medication self-management training,symptom self-monitoring training plus routine medication therapy and control group treated with routine medication therapy. All patients in both groups were assessed with Positive and Negative Symptoms Scale（ PANSS）,Insight and Treatment Attitude Questionnaire（ ITAQ）, Social Disability Screening Schedule（ SDSS） and Morningaide Rehabilitation Stats Scale（ MRSS） at baseline,the end of the 8thweek and the end of the one-year follow-up. Results（ 1） At the end of follow-up,there were significant differences in relapse rate,readmission rate and employment rate between the two groups（ P〈0. 01）.（ 2） Compared with baseline,scores of PANSS,SDSS and MRSS in study group decreased significantly and score of ITAQ in study group increased significantly at the end of the 8thweek of treatment（ P〈0. 01）; score of SDSS showed significant decrease till the end of the one-year follow-up（ P〈0. 01）.（ 3） Score of PANSS in control group was significantly higher at the end of the 8^th week than baseline（ P〈0. 01）. At the end of one-year follow-up,score of ITAQ in control group was significantly lower than that at baseline（ P〈0. 01）,scores of PANSS and SDSS in control group were significantly higher than those at baseline（ P〈0. 01）,and score of SDSS in control group was significantly higher than that at the end of the 8^th week（ P〈0. 01）.（ 4） At the end of the one-year follow-up,scores of PANSS and MRSS in both groups were significantly higher than those at the end of the 8^th week（ P〈0. 01）,while scores of ITAQ were significantly lower than those at the end of the 8thweek（ P〈0. 01） and scores of MRSS in both groups increased significantly compared with baseline（ P〈0. 01）. Scores o

关 键 词：首发精神分裂症 药物自我处置 药物自我监控 复发 社会功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]