单相抑郁与双相抑郁患者脑皮质功能连接的脑磁图特征  

Cortical functional connectivity features between bipolar and unipolar depression patients

作　　者：贾凤南 汤浩[1] 史家波[1] 毕昆[1] 花玲玲[1] 陈建准 阎锐[1] 韦秋香 卢青[1] 姚志剑[1] 

机构地区：[1]南京医科大学附属脑科医院精神四科,210029

出　　处：《中华精神科杂志》2016年第2期92-96,共5页Chinese Journal of Psychiatry

基　　金：国家高技术研究发展计划（863计划）（2015AA020509）;国家自然科学基金（81571639,81371552,61372032）;江苏省临床医学科技专项（BL2014009）;江苏省自然科学基金（BK20131074）

摘　　要：目的探讨单相、双相抑郁患者静息态下皮质间功能连接脑磁图特征的差异。方法对12例双相抑郁患者（双相抑郁组）、27例单相抑郁患者（单相抑郁组）和21名性别、年龄及受教育年限相匹配的健康对照者（对照组）进行静息态脑磁图扫描。采用同步似然性（synchronization likelihood，SL）值评估脑皮质功能连接，比较3组受试者θ、α1、α2、β及γ频段各感兴趣脑皮质区半球内及半球间SL值，在方差分析的基础上进行两两样本post—hoc检验。结果双相抑郁组较单相抑郁组及对照组左枕叶内部θ（0．249±0．087、0．181±0．029、0．196±0．032，F=8．511，P=0．001），α1（0．200±0．051、0．164±0．020、0．175±0．028，F=5．292，P=0．008）及α2[0.20．200±0．047、0．175±0．025、0．183±0．025，F=4．721，P=0．013）频段，右额叶内部β（0．186±0．027、0．166±0．024、0．159±0．026，F=4．195，P=0．020），γ（0．151±0．020、0．128±0．019、0．133±0．019，F=5．521，P=0．006）频段SL值升高。与对照组相比，双相抑郁组13（o．076±0．013与0．087±0．011，P=0．009）、γ（0．062±0．010与0．069±0．010，P=0．020）频段左右额叶间SL值增高，而单相抑郁组γ（0．057±0．013与0．050±0．005，P=0．009）频段右额叶-右顶叶顶区SL值下降。结论双相抑郁患者较单相抑郁患者额-顶-枕区功能连接进一步损害，额叶及枕叶内部局部功能连接差异可能是区分单相、双相抑郁的特征之一。Objective To explore the differences of cortico-cortical functional connectivity features among patients with bipolar and unipolar depression in resting-state. Methods Whole-head magnetoencephalography scan was performed in an resting-state condition in 12 bipolar depression patients, 27 unipolar depression patients and 21 gender-, age-, level of education- matched healthy controls. The strength of cortico-cortical functional connections was measured with synchronization likelihood （SL） value, and the SL value of long-rage as well as short-rage within θ, α1, α2, βand γfrequency bands were compared in three groups. Group-wise two post-hoe t-test was performed according to the results of ANOVA. Results Compared with the unipolar depression patients and the controls, bipolar patients showed increased local θ （0.249±0.087, 0.181±0.029, 0.196±0.032; F=8.511,P=0.001）; α1（0.200±0.051, 0.164±0.020, 0.175±0.028; F=5.292, P=0.008） and α2 （0.200±0.047, 0.175±0.025, 0.183±0.025; F=4.721, P=0.013） SL in the left occipital lobe and local 13 （0.186±0.027, 0.166±0.024, 0.159±0.026; F=4.195, P=0.020） and γ （0.151 ± 0.020, 0.128±0.019, 0.133±0.019; F=5.521, P=0.006） SL in right frontal lobe. Compared with the controls, the bipolar patients presented increased β （0.076±0.013 vs. 0.087±0.011, P=0.009） and γ（0.062±0.010 vs. 0.069 ± 0.010, P=0.020） inter-hemispheric SL between bilateral frontal lobe, whereby the unipolar patients showed decreasedγ（0.057 ±0.013 vs. 0.050 ± 0.005, P=0.009） band inter-hemispheric SL in the right frontal-parietal regions. Conclusions The bipolar depression patients displayed further dysfunction of cortical resting connectivity over the fronto-parieto-occipital regions than unipolar depression patients. The loss of temporal synchronization in the frontal and occipital lobe may be a biomarker to differentiate bipolar from unipolar depression.

关 键 词：双相情感障碍 抑郁症 脑磁图描记术 同步似然性 功能连接 

分 类 号：R749.4[医药卫生—神经病学与精神病学]