The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease:more than just a barrier  

作　　者：Sriram Balusu Marjana Brkic Claude Libert Roosmarijn E.Vandenbroucke 

机构地区：[1]Inflammation Research Center,VIB [2]Department of Biomedical Molecular Biology,Ghent University [3]Department of Neurobiology,Institute for Biological Research,University of Belgrade

出　　处：《Neural Regeneration Research》2016年第4期534-537,共4页中国神经再生研究（英文版）

基　　金：supported by the Research Foundation-Flanders (FWO);the Concerted Research Actions (GOA) of Ghent University;the Belgian Science Policy (Interuniversity Attraction Pools-IAP7/07);the Belgain Foundation of Alzheimer's Researoh (SAO);the Ministry of Education,Science and Technological Development of the Republic of Serbia (Grant ON173056) and COST Action BM1402

摘　　要：The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial（CPE） cells surrounding fenestrated capillaries.These CPE cells not only form an anatomical barrier,called the blood-cerebrospinal fluid barrier（BCSFB）,but also present an active interface between blood and cerebrospinal fluid（CSF）.CPE cells perform indispensable functions for the development,maintenance and functioning of the brain.Indeed,the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules,such as nutrients,neurotrophins,and growth factors,as well as by clearing toxic and undesirable molecules from CSF.The choroid plexus also acts as a selective entry gate for leukocytes into the brain.Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer＇s disease.In this review,we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer＇s disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy.The choroid plexus is a complex structure which hangs inside the ventricles of the brain and consists mainly of choroid plexus epithelial（CPE） cells surrounding fenestrated capillaries.These CPE cells not only form an anatomical barrier,called the blood-cerebrospinal fluid barrier（BCSFB）,but also present an active interface between blood and cerebrospinal fluid（CSF）.CPE cells perform indispensable functions for the development,maintenance and functioning of the brain.Indeed,the primary role of the choroid plexus in the brain is to maintain homeostasis by secreting CSF which contains different molecules,such as nutrients,neurotrophins,and growth factors,as well as by clearing toxic and undesirable molecules from CSF.The choroid plexus also acts as a selective entry gate for leukocytes into the brain.Recent findings have revealed distinct changes in CPE cells that are associated with aging and Alzheimer＇s disease.In this review,we review some recent findings that highlight the importance of the CPE-CSF system in Alzheimer＇s disease and we summarize the recent advances in the regeneration of brain tissue through use of CPE cells as a new therapeutic strategy.

关 键 词：Alzheimer＇s disease choroid plexus brain barrier blood-CSF barrier aging neurodegenerative diseases 

分 类 号：R749.16[医药卫生—神经病学与精神病学]