Toll-like receptor-4 antagonism mediates benefits during neuroinflammation  

作　　者：Sagar Gaikwad Challagundla Naveen Reena Agrawal-Rajput 

机构地区：[1]Laboratory of Immunology,School of Biological Sciences and Biotechnology,Indian Institute of Advanced Research

出　　处：《Neural Regeneration Research》2016年第4期552-553,共2页中国神经再生研究（英文版）

基　　金：funded by Department of Science and Technology,Government of India (Grant No.SR/CSI/59/2011(G);Gujarat State Biotechnology Mission (Grant No.GSBTM/MD/PROJECTS/.SSA/3385/2012/2013)

摘　　要：Neuroinflammation following immune activation in the central nervous system（CNS）leads to neuronal loss in specific areas of the CNS resulting in neurodegenerative disorders.Thus,fine tuning the immune responses within the brain is essential,because most of the brain diseases are associated with chronic inflammation,Neuroinflammation following immune activation in the central nervous system（CNS）leads to neuronal loss in specific areas of the CNS resulting in neurodegenerative disorders.Thus,fine tuning the immune responses within the brain is essential,because most of the brain diseases are associated with chronic inflammation,

关 键 词：neuronal tuning inflammation benefits aberrant microglia inappropriate cytokines bidirectional sepsis 

分 类 号：R741[医药卫生—神经病学与精神病学]