脾虚胃溃疡动物模型研究概况  

Review on Animal Model of Spleen Deficiency Gastric Ulcer

作　　者：张标[1] 钱会南[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《中国中医药现代远程教育》2016年第7期143-145,共3页Chinese Medicine Modern Distance Education of China

基　　金：国家自然科学基金资助项目(No:30171188)

摘　　要：脾虚是胃溃疡发病或复发的根本因素,也是溃疡发病、复发、转归和愈合的关键因素。建立稳定、可靠的动物模型,是开展疾病相关基础与临床研究的重要基础,目前脾虚胃溃疡模型的复制主要是基于脾虚证候模型和胃溃疡疾病模型两者的结合。常用的方法有耗气破气加饮食失节结合醋酸浸蚀法、苦寒泻下结合无水乙醇灌胃法、饮食偏嗜法、耗气破气结合药物诱导法,以及幽门螺杆菌感染等方法建立脾虚胃溃疡动物模型。Spleen deficiency is the underlying reason that leads to the onset or recurrence of gastric ulcer, and is also the key to its onset, recurrence, prognosis and rehabilitation. Establishing a stable and reliable animal model is an important basis for the develop-ment of disease related foundation and clinical research. The current copy of this animal model is mainly based on the combination of spleen deficiency syndrome model and gastric ulcer model. And common methods include： qi consumption and qi dissipation plus imbalanced diet with acetic acid etching, purgation due to bitter and cold medicine with ethanol gavage, diet preference, qi consump-tion and qi dissipation combined with drug induction, and Helicobacter pylori infection, etc. which were used to establish the animal model of spleen deficiency gastric ulcer.

关 键 词：脾虚证 胃溃疡 动物模型 综述 

分 类 号：R-332[医药卫生] R259