Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems  

作　　者：Yuan-qing Song Yun-long Gao Zhi-cheng Pan Yi Zhang 李洁华 Kun-jie Wang Jian-shu Li 谭鸿 Qiang Fu 

机构地区：[1]College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University [2]Research Institute for Strengthening Technology, Sichuan Institute of Building Research [3]Department of Urology, West China Hospital, Huaxi Clinical College, Sichuan University

出　　处：《Chinese Journal of Polymer Science》2016年第6期679-687,共9页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.51173118,51273124 and51273126);the National Science Fund for Distinguished Young Scholars of China(No.51425305);the Youth Science and Technology Innovation Team of Sichuan Province(No.2015TD0001);State Key Laboratory of Polymer Materials Engineering(No.sklpme2014-2-03)

摘　　要：In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane （WPU）haepafin release coating system （WPU/heparin） is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy （ATR-FTIR） and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time （APTT）, thrombin time （TT）, hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane （WPU）haepafin release coating system （WPU/heparin） is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy （ATR-FTIR） and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time （APTT）, thrombin time （TT）, hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.

关 键 词：Waterborne polyurethane HEPARIN Blend coating Hemocompatibility. 

分 类 号：TQ630.1[化学工程—精细化工]