2011-2014年我院住院患者质子泵抑制剂应用情况分析  

Utilization of Proton Pump Inhibitors in Inpatients in a Hospital during 2011-2014

作　　者：蔡杰[1] 曹堃[1] 陈妙婷[1] 郑亮[1] 黎汉坤[1] 

机构地区：[1]广东湛江中心人民医院,广东湛江524037

出　　处：《中国执业药师》2016年第4期3-5,10,共4页China Licensed Pharmacist

摘　　要：目的:调查和分析我院住院患者质子泵抑制剂(PPIs)的应用情况,评价近年我院PPIs临床应用的趋势并分析其合理性,为临床用药提供参考。方法:利用医院阳光用药监控平台提供的2011-2014年PPIs的品种、年消耗量、销售金额等数据,用限定日剂量(DDD)法,统计用药频度(DDDs)、人均DDDs、日均费用(DDDc)、药物利用指数(DUI)等,进行综合分析。结果:2011-2014年我院各类PPIs总销售金额逐年增加,2012年的增幅最明显。第2代PPIs产品埃索美拉唑、雷贝拉唑的使用呈逐年上升趋势,占主导地位的仍是第1代PPIs,相对于第2代PPIs,特别是口服制剂,有明显的价格优势。住院患者PPIs的应用有向口服制剂为主的发展趋势,仅奥美拉唑仍以注射剂应用为主。各年度PPIs的DUI均大于1.0。结论:我院的PPIs品种在临床选用上符合"有效、经济"的合理用药原则,但从人均DDDs及DUI分析,存在超剂量应用的现象。Objective ：To investigate and analyze the application of proton pump inhibitors（PPIs） in inpatients in our hospital, evaluate the application trend of PPIs in recent years and analyzes the rational administration so as to provide a reference for clinical medication. Methods ：The data on varieties, annual consumption and sales amount of PPIs from 2011 to 2014 were collected by using the drug monitoring platform, based on which a comprehensive analysis on defined daily dose, per capita frequency, defined daily cost and drug utilization index（ DUI） was performed. Results ： The total sales amount of PPIs in our hospital increased year by year from 2011 to 2014, while the most obvious increase appeared in 2012. The application of the second generation of PPIs such as esomeprazole and rabeprazole showed an increasing trend. However, compared with those of the second generation, the PPIs of the first generation still played a dominant role, especially the oral preparations with an obvious advantage in cost. The trend of application of oral preparations was the dominant, while only the omeprazole used was mainly in a form of injection. All the DUIs of PPIs in various years were more than 1.0. Conclusion ：The varieties of PPIs in our hospital conformed to the principles of ＂rational and economic application ＂. However, the analysis of per capita frequency and DUI indicated a phenomenon of excessive drug application in our hospital.

关 键 词：质子泵抑制剂 限定日剂量 用药频度 药物利用指数 

分 类 号：R573.1[医药卫生—消化系统]