三氟拉嗪对脑缺血致学习记忆障碍的保护作用  

Protective effects of trifluoperazine on learning and memory impairment induced by cerebral ischemia

作　　者：桑潮 孙啸云 韩婧凤 鲁栖霞 宋英 

机构地区：[1]徐州医科大学麻醉学院2012级,江苏徐州221004 [2]徐州医科大学麻醉生理学教研室

出　　处：《徐州医学院学报》2016年第4期262-264,共3页Acta Academiae Medicinae Xuzhou

基　　金：国家自然科学基金青年基金（31200836）;江苏省高等学校大学生创新创业训练计划项目（201510313039Y）

摘　　要：目的观察三氟拉嗪对脑缺血致学习记忆障碍的保护作用。方法将小鼠随机分成4组（n=15）：对照组、假手术组、脑缺血模型组和三氟拉嗪治疗性给药组（TFP组）。通过避暗试验和Y迷宫电刺激试验观察脑缺血是否会产生小鼠学习记忆障碍及三氟拉嗪治疗性给药对小鼠脑缺血致学习记忆障碍有无保护作用。结果避暗试验中与对照组比较，其他各组潜伏期均缩短，错误次数增多（P〈0．05）。与脑缺血模型组比较，TFP组潜伏期延长，错误次数减少（P〈0．05）。在Y迷宫电刺激实验中，与脑缺血模型组相比，其他各组的训练次数减少，学习能力较强，且记忆保持能力更好（P〈0．05）。与TFP组比较，对照组和假手术组训练次数减少，学习能力较强（P〈0．05），但记忆保持能力无明显差异（P〉0．05）。结论脑缺血会产生小鼠学习记忆障碍，三氟拉嗪治疗性给药对脑缺血所致学习记忆障碍有一定的保护作用。Objective To observe the protective effects of trifluoperazine on cerebral ischemia - induced impairment of learning and memory. Methods Mice were randomly divided into four groups （ n = 15 ） ： a control group, a sham - operated group, a cerebral ischemia model group and a TFP therapeutic drug delivery （TFP） group. Then, through the step - through test and Y - maze test, learning and memory impairment induced by cerebral ischemia in mice and the pro- tective effects of trifluoperazine were examined. Results In the step - through test, compared with the control, other groups produced shorted incubation period but more times of errors （P 〈 0.05 ）. In comparison with the cerebral ischemia model group, the incubation period was extended in the sham - operated group and TFP group, with less times of errors （ P 〈 0. 05 ）. In the Y - maze test, compared with the cerebral ischemia model group, other groups required less training times, but showed stronger learning abilities and improved memory （P 〈 0.05 ）. Compared with the TFP group, the con- trol and sham - operated groups needed reduced training times but better learning ability （P 〈 0. 05 ）, despite no signifi- cant difference in memory （P 〉 0.05 ）. Conclusion Cerebral ischemia can cause impairment of learning and memory in mice, which can be relieved by trifiuoperazine in therapeutic drug delivery.

关 键 词：三氟拉嗪 脑缺血 学习记忆障碍 小鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]