早期床边血液滤过治疗急性重症胰腺炎的临床效果  

Clinical effects of early bedside blood filtration in treatment of acute severe pancreatitis

作　　者：唐宇涛[1] 俞宁[1] 沈印[1] 

机构地区：[1]广西壮族自治区人民医院急诊科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2016年第10期1597-1601,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨早期床边血液滤过治疗急性重症胰腺炎的临床效果.方法:选取广西壮族自治区人民医院2013-10/2015-10诊治的急性重症胰腺炎患者54例,采用随机数字表法分为两组,对照组患者27例实施常规治疗,观察组患者27例联用早期床边血液滤过治疗,比较两组治疗效果.结果:治疗后,两组心率、呼吸频率、急性生理和慢性健康状况(acute physiology and chronic health evaluationⅡscore,APACHEⅡ)评分、白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)降低(P<0.05),氧合指数增加(P<0.05).观察组心率、呼吸频率、A PA C H EⅡ评分、IL-6、TNF-α、CR P低于对照组(P<0.05),氧合指数高于对照组(P<0.05),腹痛消失时间、腹胀消失时间、腹膜刺激征消失时间早于对照组(P<0.05),住院时间少于对照组(P<0.05).结论:早期床边血液滤过治疗急性重症胰腺炎的疗效显著,有助于改善患者预后.AIM： To evaluate the clinical effects of early bedside blood filtration in the treatment ofacute severe pancreatitis. METHODS： Fifty-four patients with acute severe pancreatitis treated in People’s Hospital of Guangxi Zhuang Autonomous Region from October 2013 to October 2015 were randomly divided into either a control group or an observation group, with 27 patients in each group. The control group received conventional therapy, and the observation group received early bedside blood filtration on the basis of conventional therapy. Therapeutic effects were compared between the two groups. RESULTS ： After treatment, heartrate, respiratory rate, APACHE Ⅱ score, interleukin-6, tumor necrosis factor-α, and C reactive protein significantly decreased while oxygenation index significantly increased in the two groups（P 〈 0.05）. Heart rate, respiratory rate, APACHE Ⅱ score, interleukin-6, tumor necrosis factor-α, and C reactive protein in the observation group were significantly lower than those in the control group（P 〈 0.05）. Oxygenation index in the observation group was significantly higher than that in the control group（P 〈 0.05）. Times to disappearance of abdominal pain, abdominal distension, and peritoneal irritation in the observation group were earlier than those in the control group（P 〈 0.05）. Hospitalization time in the observation group was shorter than that in the control group（P 〈 0.05）. CONCLUSION： Early bedside blood filtration has a significant effect in the treatment of acute severe pancreatitis, which is helpful to improve the prognosis of patients.

关 键 词：血液滤过 急性重症胰腺炎 临床效果 

分 类 号：R576[医药卫生—消化系统]