局部补体产生在肾脏损伤中的意义  

The renal locally produced complement and kidney injury

作　　者：李雪娟[1] 于峰[2] 丁洁[1] 

机构地区：[1]北京大学第一医院儿科,北京100034 [2]北京大学第一医院肾内科,北京100034

出　　处：《肾脏病与透析肾移植杂志》2015年第5期469-473,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(81170657);国家自然科学基金重点项目(30830105);国家重点基础研究发展计划(973;2012CB517700);北京市自然科学基金(7072080)

摘　　要：补体是一组具有酶促反应活性的血清糖蛋白。补体系统参与了多种肾脏损伤的发生与发展,以往认为导致肾脏损伤的补体成分由"肾外"细胞产生(如肝细胞等),通过循环到达肾脏而引起一系列补体介导的免疫反应及免疫损伤。近年国内外研究报道均显示,肝外组织如肾、脑、血管、肺等均能合成补体。肾脏是肝外补体合成的重要场所之一,并且肾脏局部产生的补体可能参与肾脏损伤的发生与发展。本文重点阐述肾脏局部固有细胞产生的补体成分在肾脏损伤中的意义。Complement comprises approximately 40 serum proteins,glycoproteins that exhibit enzymatic activity.Evidence increasingly indicates that the complement system plays a pivotal role in mediating renal diseases. Although complement components are produced in the liver,in recent years,many studies have shown that extrahepatic tissues,including the kidney,brain,blood vessels,lungs,can synthesize small amounts of complement components. Among extrahepatic tissues,the kidney is one of the main sites of complement synthesis. However,recent evidence also suggested that locally expressed complement proteins are involved in renal injury. This review is mainly focus on the significance of renal locally produced complement in renal diseases.

关 键 词：补体蛋白 肾脏疾病 肾脏固有细胞 

分 类 号：R692[医药卫生—泌尿科学]