肿瘤免疫抑制微环境对肿瘤免疫治疗作用的研究进展  

Study progresses of tumor immunosuppressive microenvironment in tumor immunotherapy

作　　者：张锐[1] 王智煜[1] 文孝婷 赵晖[1] 

机构地区：[1]上海交通大学附属上海市第六人民医院肿瘤内科,上海200233

出　　处：《实用肿瘤学杂志》2016年第2期167-171,共5页Practical Oncology Journal

摘　　要：肿瘤免疫抑制微环境是肿瘤微环境中起抑制免疫功能的部分。其组成包括抑制性细胞和抑制性细胞因子。近年来，因其在肿瘤免疫中的重要作用，CAR—T和PD-1／PD—L1信号通路已成为免疫治疗的研究热点，它们可通过不同的机制产生免疫抑制作用，从而促进肿瘤进展。因此，针对以上机制采取更有效的抗肿瘤疗法有可能减缓肿瘤进展。本文现就免疫抑制微环境对CAR—T疗法和PD-1／PD—L1信号通路在抗肿瘤过程中的作用进行综述。Immunosuppressive tumor microenvironment is a part of the tumor microenvironment that plays an function. It consists of suppressor cells and inhibitory cytokines. In recent years, be- cause of its important role in tumor immunity,CAR - T and PD - 1/PD - L1 signal pathway has become a hot top- ic of immunotberapy, which can suppress immune through different mechanisms to promote tumor progression. Therefore, taking more effective anti - tumor therapies against the above mechanisms is possible to rescue the pro- gress of tumor. In this article, the influence of immunosuppression microenvironment in CAR -T cell therapy and PD - 1/PD - L1 signaling pathway in the anti - tumor process is reviewed.

关 键 词：免疫抑制微环境 免疫治疗 嵌合抗原受体T细胞 程序死亡分子1 程序死亡分子1配体 

分 类 号：R730.3[医药卫生—肿瘤]