结肠癌组织中PTEN mRNA表达的意义  

Significance of PTEN mRNA expression in colon cancer

作　　者：梁艳芳 阮建波 王玲梅 陈灿 康东平 林碧华[2] 柴星星[2] 郭日昌[3] 冯锦山[2] 曾今诚[2] 

机构地区：[1]广东省东莞市第五人民医院病理科,广东东莞523905 [2]广东医学院医学分子诊断重点实验室,广东东莞523808 [3]广东医学院附属厚街医院普外科,广东东莞523900

出　　处：《广东医学院学报》2015年第5期562-564,共3页Journal of Guangdong Medical College

基　　金：国家自然科学基金(No.81500007);广东省科技计划项目(No.2014A020212298);广东省医学科研基金项目(No.A2015206;B2014294);广东省中医药局科研项目(No.20151256)

摘　　要：目的探讨结肠癌组织中PTEN m RNA表达及其临床意义。方法采用RT-PCR检测70例结肠癌及癌旁组织中PTEN m RNA表达,并分析其与临床病理特征的关系。结果结肠癌组织中PTEN m RNA表达显著低于癌旁组织[(0.246±0.162)vs(0.426±0.221),P<0.01];PTEN m RNA表达与组织学分型、TNM分期及肌层浸润有关(P<0.05),而与性别、年龄及肿瘤大小无关(P>0.05)。结论 PTEN可能参与结肠癌发生、发展过程,且与结肠癌不良预后有关。Objective To study the expression of PTEN m RNA and its clinical significance in colon cancer. MethodsPTEN m RNA expression of 70 colon cancer and juxtacancerous tissues was detected by RT-PCR. The relationship between PTEN m RNA expression and clinicopathological features of colon cancer was aslo analyzed. Results PTEN m RNA expression was lower in colon cancer than in juxtacancerous tissue（P〈0.05）. PTEN m RNA expression was associated with the histological type, TNM staging and muscular invasion（P〈0.05）, but not with the age, gender and tumor size（P〉0.05）. Conclusion PTEN might be involved in the development, progression and poor prognosis of colon cancer.

关 键 词：PTEN 结肠癌 聚合酶链式反应 

分 类 号：R735.35[医药卫生—肿瘤]