非胰岛细胞肿瘤所致低血糖一例及文献复习  

Non-islet-cell tumor induced hypoglycemia： one case report and literature review

作　　者：陆洁莉[1] 刘建民[1] 方文强[2] 陈中元[3] 金晓龙[4] 赵咏桔[1] 王卫庆[1] 宁光[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢科,上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心,200025 [2]上海交通大学医学院附属瑞金医院放射科,200025 [3]上海交通大学医学院附属瑞金医院胸外科,200025 [4]上海交通大学医学院附属瑞金医院病理科,200025

出　　处：《中华内分泌代谢杂志》2016年第4期330-334,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：通过对患者的临床资料进行分析，详细描述本院诊断的1例由巨大胸膜孤立性纤维瘤（solitary fibrous tumors of the pleura，SFTP）过度分泌胰岛素样生长因子Ⅱ导致的发作性低血糖伴血清胰岛素明显降低的病例特点。该患者发作性低血糖伴血清胰岛素水平明显降低，检查结果显示右肺存在SFTP占位，经右肺全切术后随访2年患者未再发生低血糖。对于出现发作性低血糖伴血清胰岛素明显降低临床表现的患者，应注意考虑是否为非胰岛细胞肿瘤性低血糖。A patient with severe hypoglycemia due to insulin-like growth factor （IGF） -Ⅱ secreted by a giant solitary fibrous tumor of the pleura （SFTP） was investigated through comprehensively reviewing his medical history and clinical records. The patient had severe hypoglycemia accompanied with significantly decreased serum insul.in level A solitary fibrous tumor of the pleura was found, and right pneumonectomy removed this giant tumor. Two years after the operation, the patient was fit and well with no further hypoglycemia episodes. Non-islet-cell tumor hypoglycemia should be considered in patients who have hypoglycemia episodes accompanied with significantly decreased serum insulin level.

关 键 词：胸膜孤立性纤维瘤 胰岛素样生长因子Ⅱ 非胰岛细胞肿瘤性低血糖 

分 类 号：R734.3[医药卫生—肿瘤] R587.3[医药卫生—临床医学]