鼻咽癌综合治疗患者预后影响因素分析  

Analysis of factors affecting the survival rate of patients with nasopharyngeal carcinoma

作　　者：杨东红[1] 陈华林[1] 余忠华[1] 罗海清[1] 王永存[1] 李海文[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,广州524001

出　　处：《中国肿瘤临床与康复》2016年第5期575-577,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨鼻咽癌综合治疗患者的预后影响因素。方法回顾性分析2009年1月至2011年1月间收治的94例鼻咽癌患者,均采用放化疗联合治疗。对患者的3年生存率进行统计,分析年龄、T分期、N分期、临床分期、颈动脉鞘侵犯、颅底骨质破坏、是否转移或复发、口咽部不良反应程度和治疗模式等因素,总结影响鼻咽癌综合治疗患者生存率的重要因素。结果单因素分析结果显示,T分期、临床分期、颈动脉鞘侵犯、颅底骨质破坏、治疗后复发或转移是影响鼻咽癌患者综合治疗后生存的相关因素(P<0.05)。多因素分析结果显示,颈动脉鞘侵犯、治疗后出现复发或转移是影响鼻咽癌患者生存的重要因素。结论颈动脉鞘侵犯、治疗后复发或转移是影响鼻咽癌综合治疗患者生存的重要因素,应当引起临床重视,做好相关防范及治疗措施,改善患者的预后。Objective To investigate the factors affecting the survival rate of patients with nasopharyngeal carcinoma treated by comprehensive therapy. Methods From January 2009 to January 2011 in Guangdong Medical College Affliated Hospital,a retrospective analysis was made from 94 nasopharyngeal carcinoma patients. They all accepted comprehensive chemotherapy and radiation. The 3-yr survival rate were analyzed. Age,T stage,N stage,clinical stage,invasion of the carotid sheath,skull base bone destruction,whether the transfer of shift or relapse,oropharynx toxicity degree,mode of treatment etc were analyzed. Results Univariate analysis showed that T stage,clinical stage,invasion of the carotid sheath,destruction of the base bone,treatment after recurrence or metastasis were factors accepting survival rate in patients with nasopharyngeal carcinoma（ P〈0. 05）. Multifactor analysis showed that carotid sheath involvement,recurrence or metastasis were important factors influencing the survival rates of patients with nasopharyngeal carcinoma. Conclusion Invasion of the carotid sheath,treatment after recurrence or metastasis are important factors influencing the survival of patients with nasopharyngeal carcinoma accepting comprehensive treatment.

关 键 词：鼻咽肿瘤 综合治疗 生存率 影响因素 

分 类 号：R739.63[医药卫生—肿瘤]