乳腺导管内癌伴微浸润临床病理特点分析  

Analysis of the clinical characteristics of breast ductal carcinoma in situ with microinvasion

作　　者：曾涛[1,2] 曾燕 陶爽[4] 李金平[2] 

机构地区：[1]内蒙古阿拉善盟中心医院,内蒙古阿拉善750306 [2]宁夏医科大学总医院肿瘤医院肿瘤外科,宁夏银川750004 [3]内蒙古阿拉善左旗额鲁特西路社区卫生服务中心,内蒙古阿拉善750306 [4]宁夏医科大学,宁夏银川750004

出　　处：《宁夏医学杂志》2016年第4期311-314,共4页Ningxia Medical Journal

摘　　要：目的探讨乳腺导管内癌伴微浸润(DCIS-MI)患者的临床病理特点。方法回顾性分析收治的37例乳腺导管内癌(DCIS)和64例DCIS-MI患者的临床病理资料,随机抽取乳腺浸润性导管癌(IDC)73例做对照研究。结果在组织学分级和腋淋巴结转移特征中,DCIS-MI组明显高于DCIS组而显著低于IDC组,差异有统计学意义(P<0.05);在年龄、肿瘤大小、雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体-2(Cerb B-2)阳性表达情况方面,DCIS-MI、DCIS和IDC 3组间比较差异无统计学意义(P>0.05);在Ki-67增殖方面,DCIS组中Ki-67≥14%所占比例明显低于DCIS-MI,差异有统计学意义(P<0.05),而DCIS-MI组与IDC组间比较差异统计学意义(P>0.05)。结论 DCIS-MI的临床病理特征有别于DCIS,而与IDC较为相似,对于确诊的DCIS-MI患者,应遵循IDC的诊疗指南予以诊治。Objective To explore the clinical characteristics of breast ductal carcinoma in situ with microinvasion（ DCIS-MI）. Methods The clinicopathologic data of 37 patients with DCIS and 64 patients with DCIS- MI were retrospectively analyzed,using73 patients with IDC as control. Results In the histological grade and axillary lymph node characteristics,DCIS- MI group was significantly higher than DCIS,while lower than the IDC group（ P〈0. 05）. In terms of age,tumor size,the positive rates of estrogen receptor,progesterone receptor and HER- 2,there were no statistic difference between DCIS- MI,DCIS and IDC（ P〉0. 05）. In terms of Ki- 67 proliferation,the Ki- 67 was greater than 14% in DCIS,which was significantly lower than the DCIS- MI group（ P〈0. 05）. There were no statistic difference between DCIS- MI and IDC（ P〉0. 05）. Conclusions The clinical characteristics of DCIS- MI was differ from DCIS,but was similar to IDC. The IDC treatment guidelines should be used to diagnose the DCIS- MI patients.

关 键 词：乳腺导管内癌 微浸润 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]