养心汤联合氯氮平治疗复发精神分裂症的效果  

Efficacy of Yangxin Decoction combined with Clozapine in the treatment of recurrent schizophrenia

作　　者：曹媛媛[1] 王春生[1] 高淑英[1] 李淑萍[1] 梁月竹[1] 

机构地区：[1]北京市昌平区中西医结合医院老年病三科,北京102208

出　　处：《中国医药导报》2016年第10期119-122,共4页China Medical Herald

基　　金：北京市中医药科技发展资金项目(JJ2013-48)

摘　　要：目的探讨养心汤联合氯氮平治疗复发精神分裂症的效果。方法选取2014年1~12月在北京市昌平区中西医结合医院住院的复发精神分裂症患者60例,将其随机分为实验组和对照组,每组30例。实验组采用养心汤和氯氮平治疗,对照组用安慰剂和氯氮平治疗。疗程4周。观察两组临床疗效,比较两组治疗前后不同时间点阳性与阴性症状量表（PANSS）、临床总体印象量表（CGI-S）、Sheehan残疾量表（SDS）、世界卫生组织生存质量测定量表简表（WHOQOL-BREF）评分情况。结果治疗4周后,实验组有效率（70.00%）显著高于对照组（35.71%）,差异有统计学意义（P〈0.05）。治疗2周后,实验组PANSS总分、阳性症状评分以及CGI-S评分均低于对照组,差异有统计学意义（P〈0.05）,PANSS阴性症状显著低于对照组,差异有高度统计学意义（P〈0.01）。治疗4周后,实验组SDS量表内工作、社会生活、家庭生活及家庭责任评分显著低于对照组（P〈0.05）。两组治疗4周后WHOQOL-BREF量表生理、心理、环境、社会关系指标评分差异无统计学意义（P〉0.05）。结论养心汤联合氯氮平治疗方案可有效提高临床疗效,改善复发精神分裂症患者的症状,尤其对阴性症状改善明显。Objective To investigate the efficacy of Yangxin Decoction combined with Clozapine in the treatment of recurrent chizophrenia. Methods Sixty patients with recurrent schizophrenia hospitalized in Changping Hospital of Integrated Chinese and Western Medicine from January to December 2014 were selected and randomly divided into experimental group and control group, with 30 cases in each group. Experimental group was given Yangxin Decoction and Clozapine, the control group was given placebo and Clozapine. The course was 4 weeks. The clinical efficacy of the two groups was observed, and the scores of positive and negative syndrome scale（PANSS）, clinical global impression-severity（CGI-S）, Sheehan disability scale（SDS） and World Health Organization quality of life-brief（WHOQOL-BREF） at different time points before and after treatment were compared. Results After treatment for 4 weeks, the effective rate of experimental group（70.00%） was higher than that of control group（35.71%）, the difference was statistically significant（P 〈0.05）. After treatment for 2 weeks, the total scores and scores of positive symptoms of PANSS and CGI-S scores were all lower than those of control group, the differences were statistically significant（P 〈0.05）, and the scores of negative symptoms of the experimental group were significantly lower than that of control group, the difference was highly statistically significant（P〈 0.01）. After treatment for 4 weeks, the scores of work, social life, family life and family responsibility of SDS in the experimental group were all significantly lower than those of control group（P 〈0.05）. There were no statistically significant differences of physiology, psychology, environment and social relations of WHOQOL-BREF between the two groups（P〉 0.05）. Conclusion Yangxin Decoction combined with Clozapine can effectively improve clinical efficiency and the symptoms of patients with recurrent schizophrenia, especially for the improvement of negative symptoms.

关 键 词：养心汤 氯氮平 复发精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]