骨巨细胞瘤及其辅助治疗研究现状  

Current researches for giant cell tumor of bone and its adjuvant therapy

作　　者：林育林[1,2] 张余[3] 

机构地区：[1]南方医科大学北滘医院急诊科,广东佛山528311 [2]南方医科大学研究生院 [3]广州军区广州总医院骨病关节科,510010

出　　处：《中国骨科临床与基础研究杂志》2016年第2期112-119,共8页Chinese Orthopaedic Journal of Clinical and Basic Research

基　　金：国家自然科学基金面上项目(81271957)

摘　　要：骨巨细胞瘤（GCTB）是一种常见的局部侵袭性原发性骨肿瘤,好发于20～40 岁人群的长骨骨端,生物学行为存在不确定性,局部复发率较高.临床上主要采取囊内刮除和节段切除手术治疗,其中囊内刮除结合各种物理和化学辅助疗法可提高肿瘤局部控制效果,降低肿瘤复发率.该文在复习GCTB流行病学特点、分级与诊断、手术治疗等的基础上重点综述高速磨钻技术、温度消融技术（氩气刀、微波、液氮、氩氦刀）、骨水泥填充以及化学辅助剂（如苯酚、高浓度酒精）辅助治疗的应用现状,以期对GCTB辅助治疗的选择提供参考.Being a kind of common locally-aggressive primary bone tumor, giant cell tumor of bone (GCTB) mostly occurs in metaphysis of long bones in adults between 20 to 40 years old, with uncertain biological behavior and relative high local recurrence rate. Major treatment included intralesional curettage and segmental resection, in which the combination of curettage and physical or chemical adjuvant therapy could enhance local control effects and thus reduce the recurrence of tumor. Based on reviews of epidemiological characteristics, tumor grading, diagnosis and surgical treatment, current researches of high speed drilling, temperature ablation (argon knife, microwave, liquid nitrogen, argon-helium knife), bone cement filling, as well as chemical adjuvant (phenol, high concentration ethanol and so on) therapy were focused in this paper, so as to provide references for adjuvant treatment selection in patients with GCTB.

关 键 词：巨细胞瘤 骨 流行病学 病理学 影像学诊断 综合疗法 刮除术 磨钻 高温 诱发 氩 微波 冷冻疗法 氮 氦 骨黏合剂 化学疗法 辅助 

分 类 号：R738.1[医药卫生—肿瘤] R730.59[医药卫生—临床医学]