睑板腺功能障碍与分泌物和泪液中前列腺素E_2含量的关系  

Relation between Meibomian gland dysfunction and the content of prostaglandin E_2 in the secretions and tears

作　　者：杜伟峰[1,2] 安美霞[3] 覃莉莉[3] 轩亚玲[3] 王丽莉[3] 叶琳[3] 刘彦利[3] 

机构地区：[1]南方医科大学,中国广东省广州市510515 [2]广州医科大学附属第四医院眼科,中国广东省广州市511447 [3]南方医科大学第三附属医院眼科,中国广东省广州市510630

出　　处：《国际眼科杂志》2016年第5期990-992,共3页International Eye Science

基　　金：广东省临床用药研究基金(No.2015RL07)~~

摘　　要：目的:探讨睑板腺分泌物及泪液中前列腺素E_2(prostaglandin E_2,PGE_2)含量与睑板腺功能障碍的相关性。方法:将72例120眼睑板腺功能障碍患者分为轻中度组36例60眼和重度组36例60眼,采用酶联免疫吸附试验检测睑板腺分泌物和泪液中PGE_2的含量。正常人30例60眼设为对照组,只检测泪液中PGE_2含量。结果:泪液中PGE_2含量在三组间差异有显著统计学意义(F=100.26,P<0.01),重度组泪液PGE_2含量高于轻中度组(t=5.789,P<0.01)和正常组(t=7.468,P<0.01),轻中度组泪液PGE_2含量与正常组差异无统计学意义(t=0.923,P>0.05);睑板腺分泌物PGE_2含量在两组间差异有统计学意义,重度组高于轻中度组(F=151.76,P<0.01);重度组泪液与睑板腺分泌物中PGE_2含量呈正相关(r=0.71,P<0.01);轻中度组泪液与睑板腺分泌物PGE_2含量呈正相关(r=0.30,P<0.05)。结论:睑板腺分泌物和泪液PGE_2含量对判断睑板腺功能障碍的严重程度和指导临床合理用药具有重要作用。AIM ： To investigate the correlation between the severity of M eibomian gland dysfunction（ M GD） and the prostaglandin E2（ PGE2） content in Meibomian gland secretions and tear. METHODS： Seventy- two patients with MGD were divided into mild to moderate group（ 36 patients with 60eyes） and severe group（ 36 patients with 60 eyes）. The content of PGE2 in M eibomian gland secretions and tear were tested by ELISA. Thirty healthy adults（ 60 eyes）were chosen as the control group which were only tested for PGE2 in tear.RESULTS： The differences of the content of PGE2 in tear in the three groups were significant（ F = 100. 26,P〈0. 01）,and that in the severe group was higher than that in the mild to moderate group（ t = 5. 789,P〈0. 01） and the control group（ t = 7. 468,P〈0. 01）. There was no significant difference of the content of PGE2 in tear between the mild to moderate group and control group（ t =0. 923,P〈0. 05）. The differences of the content of PGE2 in M eibomian gland secretions in three groups were significant and that in the severe group was much higher than that in the mild to moderate group（ F = 151. 76,P〈0. 01）. The content of PGE2 in M eibomian gland secretions were positive correlated to the content of PGE2 in tears in severe group（ r = 0. 71,P〈0. 01）; the content of PGE2 in M eibomian gland secretions was positive correlated to the content of PGE2 in tears in mild to moderate group（ r = 0.30,P〈0. 05）. CONCLUSION： The level of PGE2 in M eibomian gland secretions and tears plays an important role in judging the severity of M GD and guiding clinical rational drug use.

关 键 词：睑板腺功能障碍 睑板腺分泌物 前列腺素E2 相关性分析 

分 类 号：R777.13[医药卫生—眼科]