应用RBX复合物于犬前牙拔牙位点保存的实验研究  

Experiment Research of Application RBX Materials in Site Preservation Techniques in Anterior Sockets in Dogs

作　　者：康立勋[1] 王馨[1] 高艳宇[1] 

机构地区：[1]黑龙江省医院口腔种植中心,黑龙江哈尔滨150036

出　　处：《中国继续医学教育》2016年第10期15-16,共2页China Continuing Medical Education

摘　　要：目的探讨富血小板纤维蛋白(Platelet-Rich Fibrin,PRF)与重组合异种骨(Reconstituted Bone Xenograft,RBX)用于犬前牙拔牙位点即刻保存实验研究的可行性。方法 3只杂种犬,拔除每只犬双侧下颌第二、三、四前磨牙,双侧上颌第二、三前磨牙。一侧下颌第四前磨牙及上颌第二、三前磨牙牙位为实验A组,另一侧为实验B组,双侧下颌第二、三前磨牙牙位为实验C组空白对照组。A组植入PRF复合植骨材料RBX,B组植入PRF复合骨诱导活性材料(Osteoinduction Active Material,OMA),分别于术后4、8、12周处死1只犬,制备组织标本,大体观察、CBCT检查评价拔牙位点愈合情况并进行分析。结果术后4周、8周、12周CT值比较,差异有统计学意义(P<0.05),术后12周,A组高于B组和C组(P<0.05)。结论 PRF复合植骨材料RBX是一种良好的新型复合骨移植材料,具有引导骨再生作用,可减缓拔牙后牙槽嵴吸收,达到保存拔牙位点的目的。Objective To discuss the PRF/RBX in instant site preservation techniques in anterior sockets.Methods Three dogs were underwent extraction of the 2nd and 3th and the 4th premolars in bilateral of mandible,and the 2nd and the 3th premolars in bilateral of maxillary.The 4th premolars in the side of mandible and the 2th and the 3th premolars in the side of maxillary were experimental group A,in the other side were experimental group B,the 2nd and 3th premolars in bilateral of mandible were group C as blank control.Group A was immediately implanted PRF/RBX,group B was implanted PRF/OMA.One dog was sacrificed in 4 weeks later,in 8 weeks later and 12 weeks later to prepare tissue samples.The healing of extraction socket was evaluated by gross observation and photographs of CBCT.Results There was differences in 4 weeks,8 weeks and 12 weeks.At 12 weeks：CBCT value was higher in group A than that in group B and group C（P〈0.05）.Conclusion RBX is a good new bone graft material,which can guide the regeneration of new born,reduce the absorption of alveolar ridge and preserve the socket site.

关 键 词：牙齿拔除 位点保存 复合植骨材料 复合骨诱导活性材料 犬 

分 类 号：R-331[医药卫生]