黛力新辅助治疗胃食管反流病伴睡眠障碍98例疗效观察  

Observation of the Curative Effect of Deanxit on the Adjuvant Therapy of 98 Patients with GERD Accompanied by Somnipathy

作　　者：陈霞[1] 陈旭平[1] 梁红亮[1] 

机构地区：[1]成都市第六人民医院消化内科,四川成都610051

出　　处：《四川医学》2016年第4期422-425,共4页Sichuan Medical Journal

摘　　要：目的探讨黛力新对伴有睡眠障碍的胃食管反流病(GERD)患者的辅助治疗作用。方法纳入2014年11月至2015年10月在我院就诊的GERD患者,分为治疗组和对照组;所有患者均接受埃索美拉唑40mg 1次/d治疗,治疗组加用黛力新1片2次/d,治疗时间均为4周。所有患者治疗前后的反流症状和睡眠障碍的RDQ和PSQI评分,比较两组患者治疗前后的变化和有效率差别。结果治疗组和对照组治疗前平均RDQ积分为(27.18±4.57)分和(27.65±4.06)分,治疗后为(10.64±6.29)分和(14.91±5.27)分,治疗后两组比较差异有统计学意义(P<0.05)。反流症状治疗组总有效率为85.7%,对照组为72.4%,两组比较差异有统计学意义(P<0.05)。治疗组和对照组治疗前平均PSQI积分为(18.16±0.47)分和(17.92±1.09)分,治疗后为(6.85±1.34)分和(8.98±6.47)分,治疗后治两组比较差异有统计学意义(P<0.05)。睡眠障碍治疗组和对照组无1例患者达到临床痊愈标准,治疗组总有效率为79.6%,对照组为60.3%,两组比较差异有统计学意义(P<0.05)。结论黛力新联合埃索美拉唑可有效改善GERD患者睡眠障碍,提高GERD疗效,提高患者的生活质量,值得临床推广。Objective Discuss the curative effect of deanxit on the adjuvant therapy of 98 patients with GERD accompanied by somnipathy. Methods Patients with GERD who were admitted by our hospital from November 2014 to October 2015 were included and divided into treatment group and control group. All patients were accepted esomeprazole 40 mg qd,and a pill of deanxit bid was added in treatment group. The time of therapy was four weeks. The RDQ and PSQI of reflux symptoms and somnipathy of patients were graded before and after the treatment. The difference and effective rate before and after the treatment were compared,too. Results The mean RDQ grade of the treatment group and control group before treatment were（ 27. 18 ± 4. 57） and（ 27. 65 ±4. 06） respectively. The grade after treatment were（ 10. 64 ± 6. 29） and（ 14. 91 ± 5. 27） respectively and the difference is significant（ P〈0. 05）. The effective rate of reflux symptoms in treatment group is 85. 7%,and 72. 4% in control group. The difference between two groups is significant（ P〈0. 05）. The mean PSQI grade of the treatment group and control group before treatment were（ 18. 16 ± 0. 47） and（ 17. 92 ± 1. 09） respectively. The grade after treatment were（ 6. 85 ± 1. 34） and（ 8. 98 ± 6. 47） respectively and the difference is significan（ P〈0. 05）. The effective rate of somnipathy in treatment group is 85. 7%,and 72. 4% in control group.But no patients reached the standard of clinical recovery. The difference between two groups is significant（ P〈0. 05）. Conclusion Deanxit and esomeprazole can improve the somnipathy in GERD patients,the curative effect of GERD and the quality of life. This therapy has clinical spread value.

关 键 词：睡眠障碍 胃食管反流病 黛力新 

分 类 号：R571[医药卫生—消化系统]