RNA干扰在肿瘤治疗中的研究进展  

Progress of RNAi Technology for Cancer Therapy

作　　者：袁慎俊[1] 胡卫[1] 陈涛[1] 

机构地区：[1]三峡大学医学院,湖北省宜昌市443002

出　　处：《中国全科医学》2016年第12期1367-1370,1374,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(81173612)

摘　　要：恶性肿瘤是威胁人类健康的一大杀手,目前所采取的手术、放化疗等治疗措施效果并不理想。本文介绍了RNA干扰(RNAi)的相关作用机制及其在肿瘤治疗中的应用,并叙述了RNAi用于治疗时的递送方式、引起的脱靶效应和免疫反应,提示RNAi用于治疗时存在的一些问题,通过进一步的研究,基于RNAi的肿瘤治疗有望成为一种肿瘤治疗新方法。Malignant tumors are a major threat to human health,and at present the primary types of treatment such as surgery,radiation and chemotherapy do not have a good effect. This text introduced the mechanism of RNA interference（RNAi） and the application of RNAi technology in cancer therapy,described drug delivery methods of RNAi in the therapy,RNAi -induced off - target effects and immune response. Although problems still exist in the treatment by RNAi,RNAi - based cancer therapy may be a new method for the clinical treatment of cancer by further research.

关 键 词：RNA干扰 肿瘤治疗方案 脱靶效应 免疫反应 

分 类 号：R730.5[医药卫生—肿瘤] R394.114[医药卫生—临床医学]