直肠癌白细胞介素-6的表达与临床病理因素的相关性研究  

Correlation between IL-6 expression and clinicopathologic features in rectal cancer

作　　者：刘晓平[1] 周小青[2] 邓伟[1] 钟宝元[1] 曾祥福[1] 吴平辉[1] 

机构地区：[1]赣南医学院第一附属医院胃肠外科,江西赣州341000 [2]赣南医学院第二附属医院外一科,江西信丰341600

出　　处：《中国现代医学杂志》2016年第6期23-26,共4页China Journal of Modern Medicine

基　　金：江西省教育厅科学技术研究项目(No:GJJ14677)

摘　　要：目的研究白细胞介素-6(IL-6)在直肠癌中的表达及与临床病理因素的相关性。方法选取2013年2月-2014年1月在赣南医学院第一附属医院诊断为直肠癌的患者49例为直肠癌组,取其肿瘤组织以及癌旁正常组织;选取同一时间段健康体检者30例作为对照组。应用免疫组织化学和血清学检测IL-6在直肠癌患者中的表达,分析其与临床病理因素的关系。结果 IL-6蛋白在直肠癌组织中的表达明显高于癌旁组织。IL-6蛋白表达与直肠癌患者的年龄、性别、肿瘤分化程度以及淋巴结转移无关,与临床分期有关。直肠癌组术前血清IL-6水平明显高于对照组。Ⅲ、Ⅳ期直肠癌患者的血清IL-6水平明显高于Ⅰ、Ⅱ期;有淋巴结转移患者的IL-6水平明显高于无淋巴结转移者,差异有统计学意义(P<0.05)。结论 IL-6的高表达与直肠癌病程发展密切相关,可能是肿瘤转移的关键因子之一。Objective To study the correlation between IL-6 and clinicopathologic features in rectal cancer.Methods IL-6 expression was detected by immunohistochemistry and peripheral blood assay in rectal cancer tissues and pericarcinomatous tissues of 49 rectal cancer patients, and 30 healthy people for physical examination were taken as controls. Then its relationship with clinicopathologic features was analyzed. Results IL-6 expression in the rectal cancer tissues was higher than that in the pericarcinomatous tissues. IL-6 expression had no relationship with age, gender, histological type or lymph node metastasis. However, IL-6 protein expression was correlated with clinical stage of rectal cancer. Peripheral blood IL-6 level in the rectal cancer patients was higher than that in the healthy persons before operation. Serum IL-6 level was significantly associated with clinical stage and lymph node metastasis（P〈0.05）. Conclusions High-expression of IL-6 is closely associated with the development of rectal cancer. IL-6 may be a key factor of tumor metastasis.

关 键 词：直肠肿瘤 白细胞介素-6 肿瘤转移 

分 类 号：R735.3[医药卫生—肿瘤]