北京市空气污染对湿疹患者门诊量影响的时间序列研究  

A time-series study on the association between air pollution and daily visits outpatients with eczema in Beijing

作　　者：吕宏梅[1] 王旭英[2] 王巧伟[3] 李咏荷 刘玮[1] 潘小川[2] 

机构地区：[1]安徽医科大学研究生学院,安徽合肥230032 [2]北京大学公共卫生学院劳动卫生与环境卫生学系,北京100191 [3]中国人民解放军空军总医院皮肤科,北京100142

出　　处：《临床皮肤科杂志》2016年第5期328-331,共4页Journal of Clinical Dermatology

摘　　要：目的:研究大气污染与湿疹日门诊量的相关性。方法:收集2012年4月—2014年4月中国人民解放军空军总医院皮肤科湿疹患者的日门诊量资料,从北京市环境保护监测中心获得同期大气污染物浓度资料,以及从国家气象共享平台获得同期气象监测数据,采用基于广义相加模型的时间序列分析方法,在控制长期和季节趋势、控制节假日效应、气象因素等混杂因素的基础上,分析研究期间大气主要污染物(PM_(2.5)、PM_(10)、SO_2及NO_2)的日平均浓度与湿疹患者日门诊量的关系。结果:大气污染物与湿疹日门诊量显著相关,单污染物模型显示,大气PM_(2.5)、PM_(10)、SO_2及NO_2浓度每升高10μg/m^3,湿疹患者的日门诊量分别增加0.3%(0.1,0.4)、0.3%(0.2,0.4)、0.4%(0,0.9)及1.6%(1.1,2.0),各污染物浓度均在当日浓度(Lag0)最为显著;双污染物模型显示,气态污染物之间关联强度最强。结论:大气主要污染物PM_(2.5)、PM_(10)、SO_2及NO_2能增加湿疹患者的日门诊量。Objective： To analyze the association between air pollution and visits of outpatients with eczema in Beijing. Methods： The outpatient visits of eczema data were obtained from the Air Force General Hospital between April 2012 and April 2014. Meanwhile, the concentration of air pollutants data and the meteorological data were collected from the Beijing Municipal Environmental Protection Center and China meteorological data sharing service system, respectively. The generalized additive model based on time-series analysis was used to analyze the relationship between the daily average concentration of main air pollutants （PMzs, PMl0, SO2 and NO2） and daily average outpatient visits of eczema, after adjusting the influences of long term and seasonal trends, holidays and the weather conditions. Results： Air pollution was significantly associated with outpatient visits of eczema in Beijing. An increase of 10 ~g/m3 in PMzs, PM10, SO2 and NO2 could increase visits of outpatients with eczema by 0.3%, 0.3%, 0.4%, and 1.6% respectively in the single-pollutant model. The concentration of those pollutants in the same day（Lag0） showed the most significant association with the number of daily visit. In the double pollutant models, a strongest association was found between the gaseous pollutants and outpatients＇visit. Conclusion： The increase of the main air pollutants （PM2.5, PM10, SO2 and NO2） is a risk factor for the eczema in Beijing.

关 键 词：湿疹 空气污染 时间序列分析 北京 

分 类 号：R751[医药卫生—皮肤病学与性病学]