有氧运动对乳腺癌化疗患者癌因性疲乏的影响及相关机制  

Effects and related mechanisms of aerobic exercise on cancer-related fatigue in breast cancer patients undergoing chemotherapy

作　　者：曹玉瑶 宋祎[1] 陈凤敏[1] 徐锦江[2] 

机构地区：[1]辽宁医学院研究生院,121000 [2]辽宁医学院附属第一医院

出　　处：《天津医药》2016年第4期401-404,共4页Tianjin Medical Journal

基　　金：辽宁省科技厅课题(2013225305)

摘　　要：目的探讨有氧运动对乳腺癌化疗患者癌因性疲乏的影响及相关机制。方法 60例根治术术后欲进行化疗的乳腺癌患者随机分为运动组和对照组,各30例。对照组给予常规护理。运动组除常规护理外,在化疗第1天开始有氧运动干预,直到化疗结束。使用Piper疲乏修订量表(RPFS)对疲乏程度进行评估。分别在化疗前、化疗结束和化疗后4周检测两组患者的血红蛋白(Hb)水平、最大摄氧量(VO2max)和RPFS得分情况。结果两组Hb水平在化疗前、化疗结束和化疗后4周差异均无统计学意义(P>0.05);化疗结束和化疗后4周,两组Hb水平均低于化疗前(P<0.05)。化疗前两组VO2max和RPFS得分差异无统计学意义(P>0.05);化疗结束和化疗后4周,运动组VO2max和RPFS得分与化疗前相比差异均无统计学意义(P>0.05),对照组VO2max低于化疗前水平,RPFS得分高于化疗前水平(均P<0.05)。结论化疗期间有氧运动能够有效缓解化疗导致癌因性疲乏加重的情况,这可能与有氧运动能对抗VO2max降低有关。Objective To investigate the effects of aerobic exercise during chemotherapy on cancer-related fatigue inbreast cancer patients, and related mechanism thereof. Methods Sixty breast cancer patients who underwent radical surgerywere randomly assigned to exercise group and control group, 30 patients for each group. Patients in exercise group receivedregular nursing care plus aerobic exercise during chemotherapy, while patients in control group only received regular nursingcare. The revised Piper fatigue scale（RPFS） was used to assess the fatigue degree. Values of hemoglobin concentration（Hb）,maximal oxygen uptake（VO2max） and RPFS scores were detected before chemotherapy, at the end of chemotherapy and 4 weeksafter chemotherapy, respectively. Results There was no significant difference in Hb concentration before chemotherapy,at the end of chemotherapy and 4 weeks after chemotherapy between two groups（P0.05）. The level of Hb was significantlylower at the end of chemotherapy and 4 weeks after chemotherapy than that before chemotherapy in two groups（P0.05）.There were no significant differences in VO2 maxand RPFS score before chemotherapy between two groups（P0.05）. At theend of chemotherapy and 4 weeks after chemotherapy, there were no significant differences in VO2 maxand RPFS scores thanthose before chemotherapy in exercise group（P0.05）. In control group, value of VO2 maxwas significantly lower at the endof chemotherapy and 4 weeks after chemotherapy than that before chemotherapy（P0.05）, RPFS score was significantly higherthan that before chemotherapy（P0.05）. Conclusion Aerobic exercise during chemotherapy can be effectively againstcancer-related fatigue, which may be related to the inhibitory effect of aerobic exercise on debasement of VO2 max.

关 键 词：疲劳 肿瘤 体育和训练 血红蛋白类 氧耗量 癌因性疲乏 有氧运动 最大摄氧量 Piper疲乏量表 

分 类 号：R737.9[医药卫生—肿瘤]