相干光断层扫描在诊断原发性开角型青光眼中的应用  

Application of optical coherence tomography in diagnosis of primary open angle glaucoma

作　　者：张娣[1] 杨静[1] 廖沁[1] 黄舸[1] 

机构地区：[1]成都市第二人民医院眼科,610017

出　　处：《临床眼科杂志》2016年第2期117-120,共4页Journal of Clinical Ophthalmology

摘　　要：目的探讨相干光断层扫描(OCT)在原发性开角型青光眼(POAG)诊断中的应用。方法选择POAG患者69例(84只眼,POAG组)及正常人32例(32只眼,正常对照组)。POAG患者分为早期POAG组29例(29只眼),进展期POAG组24例(28只眼),晚期POAG组16例(27只眼)。应用Cirrus HD-OCT行视网膜神经纤维层(RNFL)、视盘、黄斑旁中心凹神经节细胞层(GCL)扫描,观察各组参数。结果 POAG组患者与对照组相比,RNFL厚度明显变薄;平均杯盘比、垂直杯盘比、视杯容积显著增加,盘沿面积显著降低;黄斑旁中心凹GCL厚度明显变薄,均有统计学意义。结论 RNFL、视盘参数、黄斑旁中心凹GCL厚度是诊断POAG的敏感指标,OCT检测有助于POAG患者的早期诊断。Objective To evaluate the role of optical coherence tomography（ OCT） in diagnosis of primary open angle glaucoma（ POAG）. Methods The retinal nerve fiber layer（ RNFL）,optic disc and parafoveal ganglion cell layer（ GCL） were measured by Cirrus HD-OCT in 69 POAG patients（ 84 eyes） and 32 normal subjects（ 32 eyes）. POAG patients were further divided into early stage（ 29 cases,29 eyes）,advanced stage（ 24 cases,28eyes） and late stage groups（ 16 cases,27 eyes）. Measurement results were analyzed and compared. Results RNFL thickness in POAG patients was significantly thinner at all four quadrants than in normal subjects. The average cup / disc ratio,vertical cup / disc ratio,and cup volume increased significantly,and rim area was reduced significantly in POAG patients. Parafoveal GCL was significantly thinner in POAG patients. Conclusions POAG can be sensitively diagnosed by measuring RNFL thickness,optic disc parameters and parafoveal GCL thickness with OCT. This test may be an early diagnostic method for potential POAG patients.

关 键 词：相干光断层扫描 视网膜神经纤维层 视盘 神经节细胞层 原发性开角型青光眼 

分 类 号：R775[医药卫生—眼科]