吡拉西坦与尼莫地平治疗脑梗死后血管性痴呆患者的临床疗效  

Efficacy of vascular dementia Piracetam after cerebral infarction treated with nimodipine Zhuang source

作　　者：庄源[1] 安丽荣[1] 徐文丽[1] 魏广宽[1] 

机构地区：[1]黑龙江省医院神经内二科,黑龙江哈尔滨150036

出　　处：《中国药物经济学》2016年第4期72-73,共2页China Journal of Pharmaceutical Economics

摘　　要：目的探讨吡拉西坦与尼莫地平联合治疗脑梗死后血管性痴呆(Va D)患者的临床疗效。方法选取2013年1月至2015年1月黑龙江省医院神经内二科收治的脑梗死后Va D患者72例,按随机数字表法分为观察组与对照组,每组36例。观察组患者采用吡拉西坦与尼莫地平联合治疗,对照组患者单纯采用尼莫地平治疗,比较两组患者的治疗效果。结果治疗后,观察组患者的日常生活能力量表评分及简易智能状态检查量表评分均显著高于对照组,差异均有统计学意义(均P<0.05);两组患者的不良反应发生率差异无统计学意义(P>0.05)。结论对脑梗死后Va D患者应用吡拉西坦与尼莫地平联合治疗,较单独应用尼莫地平治疗能够显著改善患者的认知功能与日常生活活动能力,且不良反应无明显增加。Objective To analyze Piracetam cerebral infarction treated with nimodipine vascular dementia（Va D） patients.Methods Methods 72 patients with cerebral infarction after cerebral infarction in the Department of Neurology from January 2013 to January 2015 were selected and divided into the observation group and the control group according to the random number table method, two cases were divided into the observation group and the control group,36 cases in each group.Observation group Piracetam combined treatment with nimodipine,nimodipine group therapy alone,more therapeutic effect.Results After treatment,the observation group ADL score and MMSE scores were significantly higher（P〈0.05）;no significant difference in the rate of adverse events between the two groups（P〉0.05）.Conclusion Va D patients after cerebral infarction Piracetam combination therapy compared with nimodipine nimodipine alone can significantly improve cognitive function in patients with activities of daily living,and no significant increase in side effects.

关 键 词：脑梗死 血管性痴呆 吡拉西坦 尼莫地平 临床疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]