缺氧诱导因子-1α蛋白在乳腺癌中的表达及临床意义  

Expression and clinical significance of HIF-1α in breast cancer

作　　者：刘擘[1] 李芳[1] 韩晓东[1] 田延锋[1] 赵增仁[1] 

机构地区：[1]河北医科大学第一医院普外科,050031

出　　处：《中华内分泌外科杂志》2016年第2期135-138,143,共5页Chinese Journal of Endocrine Surgery

基　　金：河北省科技计划项目（14277755D）

摘　　要：目的检测缺氧诱导因子-1α蛋白（hypoxia—induciblefactor-1α，HIF-1α）在乳腺癌中的表达情况，运用统计学方法分析HIF-1α与乳腺癌临床病理学特征。探讨HIF-1α作为乳腺癌治疗新靶点的可行性。方法选择2013年1月至2013年12月在河北医科大学第四医院乳腺中心手术切除的56例女性原发性乳腺癌患者的癌组织标本。采用免疫组化法检测癌组织中HIF-1α蛋白的表达状况，统计分析HIF-1α蛋白表达与乳腺癌各项临床病理参数的相关性。结果HIF-1α蛋白在乳腺癌组织中的阳性表达率73．2％（41／56）及高表达率41．1％（23／56）均明显高于乳腺良性肿瘤组（P=0．000）。HIF-1α蛋白表达与乳腺癌肿瘤直径、分期、组织学分级和淋巴结转移状况及HER2的表达正相关，与ER的表达负相关。结论乳腺癌组织中HIF-1α的高表达与预后差显著相关，HIF-1α的高表达是乳腺癌的危险因素，有助于判断肿瘤的侵袭性和转移能力。HIF-1α蛋白与HER2蛋白一样均为乳腺癌的危险因素，在乳腺癌的进展中可能具有协同作用。Objective To detect the expression of hypoxia-induciblc factor-1α （HIF-1α） in breast cancer and to investigate the feasibility of HIF-1α as a new therapy target for breast cancer. Methods 56 cancer tissue specimens of women with primary breast cancer admitted from Jan. 2013 to Dec. 2013 in the Fourth Hospital of Hebei Medical University Breast Center were selected. Immunohistochemistry was used to detect the expression of HIF-1α protein in cancer tissues. The relation between HIF-1α protein expression and the clinicopathological parameters was analyzed. Results The positive expression rate of HIF-1α protein in breast cancer was 73.2% （41/56） and its high expression rate was 41.1% （23/56）, which were significantly higher than those in benign breast tumor group （P=0.000）. HIF-1α protein expression was positively correlated with breast tumor size, stage, histological grade, lymph node metastasis and the expression of HER2, and it was negtively correlated with ER. Conclusions High expression of HIF-1α in breast cancer was significantly associated with poor prognosis. HIF-1α protein is also a risk factor for breast cancer as well as HER2, and they may have a synergistic role in the progression of breast cancer.

关 键 词：缺氧诱导因子-1α蛋白 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]