加锌膳食纤维对烫伤休克大鼠肠道血流动力学的影响  

INFLUNCE OF ZINC DIETARY FIBER ON INTESTINAL HEMODYNAMICS IN RATS OF BURN SHOCK

作　　者：贺瑞新 张红梅 赵春香 于明忠 王瑞刚 李冬梅 石秋艳 

机构地区：[1]华北理工大学附属医院,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2016年第4期575-578,共4页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生与计划生育委员会指令性课题(编号:20150084);中国煤炭工业协会2015年度科学技术指导性项目(MTKJ2015-305)

摘　　要：目的研究加锌膳食纤维对烫伤休克大鼠肠道血流动力学的影响。方法选择健康Wistar大鼠80只,雌雄各半,体重(200±20)g,自制Ⅲ度30%体表面积(TBSA)烫伤模型,将大鼠随机分为四组:A组(单纯烫伤组);B组(烫伤+膳食纤维组);C组(烫伤+锌+膳食纤维组);D组(对照组)。每组每个时间点(6h、12h、24h、48h、72h5个时间点)8只动物。对比四组的动脉平均压(MAP)、腹部经皮氧分压(PtcO_2)、肠黏膜血流量。结果动脉平均压(MAP)、心率(HR)与对比组比较,B、C二组的情况明显降低,P<0.05,具有统计学意义,A组变化不明显,P>0.05,无统计学意义;腹部经皮氧分压PtcO2、肠黏膜血流量与对比组比较,B、C二组的情况明显升高,P<0.05,具有统计学意义,A组变化不明显,P>0.05,无统计学意义。结论烫伤早期应用加锌膳食纤维改善烫伤大鼠的循环状态,对早期的休克进行纠正,以此增加肠黏膜的血流量。ObjectiveTo investigate the effect of Zinc dietary fiber on intestinal hemodynamics for burn shock rats.Methods Totally 80 healthy Wistar rats were selected,half male and half female,body weight（200±20）g,homemadeⅢ degree of 30% body surface area（TBSA）burn model was established.All rats were randomly divided into four groups,group A（alone scald group）,group B（scald plus dietary fiber）,group C（scald plus Zn and dietary fiber）,group D（control group）.There were 8 animals in each group at each time point（6 hours,12 hours,24 hours,48 hours,72 hours 5 time points）.The mean arterial pressure（MAP）,abdominal transcutaneous oxygen pressure（PtcO2）and blood flow of intestinal mucosal were compared among 4 groups.Results Compared with the control group,the mean arterial pressure（MAP）and heart rate（HR）in group B and group C were significantly reduced,P〈0.05,but they didn＇t change significantly in group A,P〉0.05.Abdominal transcutaneous oxygen PtcO2 and intestinal mucosal blood flow of group B and C,contrast control group,were significantly higher situation,P〈0.05,while in group A didn＇t change significantly,P〉0.05.Conclusion Early applications Zinc dietary fiber can improve circulation of scalded rats,correct early shock,and can increase blood flow to the intestinal mucosa.

关 键 词：加锌 膳食纤维 肠黏膜 烫伤休克 

分 类 号：R644[医药卫生—外科学]