前列腺癌组织中Glypican-3蛋白的表达及意义  

Expression and significance of Glypican-3 in prostate cancer

作　　者：李勇[1] 赵新鸿[1] 孟晓东[1] 陈涛[1] 刘健[1] 邱建宏[1] 

机构地区：[1]中国人民解放军白求恩国际和平医院泌尿外科,河北石家庄050082

出　　处：《河北医科大学学报》2016年第4期397-399,共3页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题(20150370)

摘　　要：目的探讨磷脂酰肌醇蛋白聚糖3(Glypican-3,GPC-3)蛋白在前列腺癌组织中的表达及意义。方法选取前列腺癌和前列腺增生组织各30例标本,采用免疫组织化学SP法染色,分析GPC-3蛋白在前列腺癌及前列腺增生组织中的表达情况。结果 GPC-3蛋白在前列腺癌组织中的阳性表达率高于前列腺增生组织(P<0.05),Gleason评分≥7分的前列腺癌组织中GPC-3蛋白的阳性表达率高于Gleason评分<7分者(P<0.05)。结论GPC-3蛋白在前列腺癌组织中高表达,可能与前列腺癌的发生、发展有关。Objective To investigate the expression and significance of glypican-3（GPC-3）in prostate cancer.Methods A total of 30 cases of prostate cancer tissues and 30 cases of benign prostatic hyperplasia tissues were included in the study with the immunohistochemical S-P method to detect the expression of GPC-3in prostate cancer and benign prostatic hyperplasia.Results The positive rates of GPC-3expression in prostate cancer tissues was significantly higher than that in benign prostatic hyperplasia tissues（P〈0.05）.The positive rates of GPC-3expression in prostate cancer tissues with gleason score equal to or more than 7was significantly higher than that with gleason score less than 7（P〈0.05）.Conclusion High expression of GPC-3in prostate cancer may play an important role in development of prostate cancer.

关 键 词：前列腺肿瘤 前列腺增生 磷脂酰肌醇蛋白聚糖类 

分 类 号：R737.25[医药卫生—肿瘤]