液体营养餐负荷试验评估功能性消化不良患者胃感觉功能的研究  

The investigation of liquid nutrient load test for the evaluation of functional dyspepsia

作　　者：王慧芬[1,2] 姚树坤[1,2] 刘芳[1,2] 杜时雨[1] 王淼[1] 张艳丽[1] 

机构地区：[1]中日友好医院消化内科,北京100029 [2]中国医学科学院北京协和医学院研究生院,北京100730

出　　处：《疑难病杂志》2016年第5期449-452,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：国家科技部"十二五"支撑计划(2014BAl08B02)

摘　　要：目的通过液体营养餐负荷试验,评价功能性消化不良(FD)患者的胃感觉功能。方法选择2014年8月—2015年2月中日友好医院消化内科门诊就诊的FD患者44例为病例组,其中男22例,女22例,上腹痛综合征(EPS亚组)17例,餐后不适综合征(PDS亚组)27例;纳入健康志愿者44例为健康对照组,男22例,女22例。根据症状进行FD分型,通过液体营养餐负荷试验记录,比较患者的初始感觉阈值时饮入量(TV)和最大饱足感时饮入量(MV)。结果病例组患者的TV明显小于健康对照组[(229.7±95.4)ml vs.(269.8±36.1)ml,t=-2.609,P=0.012],MV也明显小于健康对照组[(506.1±220.2)ml vs.(755.9±79.9)ml,t=7.073,P<0.01]。病例组男性患者与健康对照组男性的TV相比差异无统计学意义(P>0.05),女性患者的TV与健康对照组女性相比明显减少[(194.6±81.8)ml vs.(242.7±15.2)ml,t=-2.718,P=0.012]。病例组男性患者的MV较健康对照组男性明显减少[(584.9±256.4)ml vs.(800.9±80.6)ml,t=-3.770,P=0.001],女性患者的MV亦较健康对照组女性明显减少[(427.3±143.4)ml vs.(710.9±48.3)ml,t=8.792,P<0.01]。病例组患者中,女性的TV较男性明显减少[(194.6±81.8)ml vs.(264.8±96.7)ml,t=-2.601,P=0.013],女性的MV亦较男性明显减少[(427.3±143.4)ml vs.(584.9±256.4)ml,t=-2.517,P=0.016]。PDS亚组和EPS亚组患者的TV、MV差异均无统计学意义(P>0.05);2组男性患者的TV、MV相比差异亦无统计学意义(P>0.05);PDS亚组女性患者的TV较EPS亚组女性患者明显减少[(156.2±63.6)ml vs.(238.0±80.3)ml,t=3.165,P=0.005],MV亦较EPS亚组女性明显减少[(373.1±117.7)ml vs.(493.0±143.9)ml,t=2.348,P=0.029]。EPS亚组中女性与男性的TV及MV差异均无统计学意义(P>0.05);PDS亚组中女性的TV明显小于男性[(156.2±63.6)ml vs.(262.5±107.8)ml,t=-3.018,P=0.005],女性的MV也明显小于男性[(373.1±117.7)ml vs.(568.1±222.0)ml,t=-2.711,P=0.009]。早饱感与MV呈负相关(r=-0.236,P=0.048),即MV小者更容易出现早饱的症状。未发�Objective To analyze the correlation between liquid nutrient load test（LNLT）and the gender,subtype in functional dyspepsia（FD） patients.Methods A total of 44 patients from China Japan Friendship Hospital were enrolled and gender,age and subtype were recorded.Then all patients received the LNLT and recorded the threshold volume（TV）and maximal volume（MV）.Results A total of 44 patients（22 males and 22 females） have completed the trial.The patients were divided into 2 subtypes（17 cases in EPS,27 cases in PDS）.There were 44 healthy control group,22 females and 22 males.TV of FD were lower than TV of healthy control group[（229.7 ±95.4）ml vs（269.8 ±36.1）ml,t =-2.609,P =0.012],MV of FD were lower than MV of healthy control group[（506.1 ±220.2）ml vs（755.9 ±79.9） ml,t =7.073,P〈0.01].There was no significant difference between TV of males in FD and TV of males in HS（P〈0.05）.TV of females in FD were lower than TV of females in HS[（194.6 ±81.8） ml vs.（242.7 ± 15.2）ml,t =2.718,P =0.012].MV of males in FD were lower than TV of males in HS[（584.9 ±256.4）ml vs.（800.9 ±80.6）ml,t =3.770,P =0.001].MV of females in FD were lower than TV of females in HS[（427.3 ±143.4） ml vs.（710.9 ±48.3） ml,t =8.792,P〈0.01].TV of males were higher than TV of females[（194.6 ±81.8）ml vs.（264.8 ±96.7） ml,t =-2.601,P =0.013].MV of males were higher than MV of females[（427.3 ±143.4） ml vs.（584.9 ±256.4） ml,t =-2.517,P =0.016].There were 17 patients in subtype of EPS and 27 patients in subtype of PDS.There was no significant difference in TV and MV between EPS and PDS.TV of females in PDS were lower than TV of females in EPS[（156.2 ± 63.6） ml vs.（238.0 ± 80.3） ml,t =3.165,P =0.005],MV of females in PDS were lower than MV of females in EPS[（373.1 ± 117.7） ml vs.（493.0 ±143.9） ml,t =2.348,P = 0.029].There was no significant difference in TV and MV between males and females in EPS.TV of females were lower than TV of males in PDS[（156.2

关 键 词：功能性消化不良 液体营养餐负荷试验 上腹痛综合征 餐后不适综合征 

分 类 号：R57[医药卫生—消化系统]